Therapy for Stage IV NSCLC With Driver Alterations: ASCO Living Guideline Update 2026.3.2

Therapy for Stage IV NSCLC With Driver Alterations: ASCO Living Guideline Update 2026.3.2

Author: American Society of Clinical Oncology (ASCO) July 28, 2026 Duration: 9:00

Dr. Sonam Puri joins the podcast to share the update to the living guideline on stage IV NSCLC with driver alterations. Dr. Puri discusses the practice-changing evidence reviewed for both NTRK rearrangements, including the TRIDENT-1 trial, and HER2 activating mutations, including the Beamion LUNG-1 study. She shares how these results impacted the clinical practice guideline with the addition of repotrectinib and zongertinib, what these new TKIs mean for patients, and where the panel is waiting for additional randomized data to clarify the role of therapeutic options. Dr. Puri encourages listeners to stay tuned for future updates to the living guideline as new evidence is published.

Read the full living guideline "Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.2" at www.ascopubs.org/guidelines/therapy-stage-iv-non-small-cell-lung-cancer-driver-alterations"

LINK TO FULL TRANSCRIPT


The ASCO Guidelines podcast, from the American Society of Clinical Oncology, serves as an authoritative audio companion for oncology professionals. Each episode delves into the rationale and practical application of the society's latest evidence-based clinical practice guidance. You'll hear directly from the experts who helped develop these critical recommendations, gaining a deeper understanding of the data and discussions that shape contemporary cancer care. This podcast provides a vital channel for staying current in a rapidly advancing field, translating complex guidelines into actionable knowledge for clinical practice. It’s an essential resource for anyone dedicated to implementing the highest standards in oncology, offering clarity and context that goes beyond the published document. Tune in for a focused exploration of how new research directly informs treatment pathways and patient management strategies.
Author: Language: en-us Episodes: 50

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