Treatment of Multiple Myeloma: ASCO Living Guideline Update 2026.1.1

Treatment of Multiple Myeloma: ASCO Living Guideline Update 2026.1.1

Author: American Society of Clinical Oncology (ASCO) June 29, 2026 Duration: 17:45

Dr. Rahul Banerjee joins the podcast to discuss the latest update to the living guideline on the treatment of multiple myeloma. He explains how sensational results from the MajesTEC-3 trial, which evaluated teclistamab plus daratumumab, prompted a major shift in the recommendations for patients with relapsed or refractory disease. Dr. Banerjee details why immunotherapies, specifically CAR T-cell therapy and bispecific antibodies, are now the preferred treatment options at first relapse over traditional triplets. He also provides context on evidence that did not lead to recommendation changes, the importance of individualized decision-making when choosing between immunotherapy options, and what future updates may be on the horizon, including data on CELMoDs.

Read the full living guideline, "Treatment of Multiple Myeloma: ASCO Living Guideline, Version 2026.1.1," at www.ascopubs.org/guidelines/treatment-multiple-myeloma-asco-living-guideline


The ASCO Guidelines podcast, from the American Society of Clinical Oncology, serves as an authoritative audio companion for oncology professionals. Each episode delves into the rationale and practical application of the society's latest evidence-based clinical practice guidance. You'll hear directly from the experts who helped develop these critical recommendations, gaining a deeper understanding of the data and discussions that shape contemporary cancer care. This podcast provides a vital channel for staying current in a rapidly advancing field, translating complex guidelines into actionable knowledge for clinical practice. It’s an essential resource for anyone dedicated to implementing the highest standards in oncology, offering clarity and context that goes beyond the published document. Tune in for a focused exploration of how new research directly informs treatment pathways and patient management strategies.
Author: Language: en-us Episodes: 50

ASCO Guidelines
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