BS 211 Molecular Biologist Seth Grant

BS 211 Molecular Biologist Seth Grant

Author: Ginger Campbell, MD August 25, 2023 Duration: 1:10:15

This episode of Brain Science features the return of molecular biologist Seth Grant. We briefly review his decades of research into the complexity of the protein structure of the synapse and then we focus on his most recent paper, which describes how the life-span of synapse proteins appears to change as animals age. Grant reflects of the significance of this finding both for animal research and human medicine.

Papers discussed in this episode: 

  • Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M., O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A., Fransén, E., & Grant, S. G. N. (2022). A brain atlas of synapse protein lifetime across the mouse lifespan. Neuron, 110(24), 4057–4073.e8. https://doi.org/10.1016/j.neuron.2022.09.009
  • Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N. H., Fransén, E., & Grant, S. G. N. (2020). A brainwide atlas of synapses across the mouse life span. Science (New York, N.Y.), 369(6501), 270–275. https://doi.org/10.1126/science.aba3163

Seth Grant has previously appeared on Brain Science several times including BSP 51, BSP 101, BS 137, BSP 150 and BS 176.

 

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How does a three-pound organ of wet tissue-the human brain-create the entire subjective experience of being you? Brain Science with Ginger Campbell, MD: Neuroscience for Everyone tackles that profound mystery and many others, translating complex research into compelling conversations. Hosted by Dr. Ginger Campbell, an experienced physician and 2022 Podcast Hall of Fame inductee, this podcast digs into the latest books and ideas in neuroscience with leading researchers and authors. The discussions move beyond dry academic summaries to explore the real-world implications of brain science-how it shapes our health, fitness, mental life, and understanding of consciousness itself. What you'll hear are clear, thoughtful dialogues that make cutting-edge discoveries accessible, whether you have a PhD or simply a deep curiosity about why we think, feel, and behave the way we do. Each episode is an investigation into the mechanisms behind perception, memory, emotion, and decision-making, revealing the biological underpinnings of our shared humanity. This is a long-running podcast dedicated to the idea that everyone can engage with these fundamental questions, guided by a host whose medical background and genuine enthusiasm provide a trustworthy and engaging pathway into the material. Listen for a deeper appreciation of the most fascinating subject there is: the human mind, explored through the rigorous yet welcoming lens of neuroscience.
Author: Language: English Episodes: 100

Brain Science with Ginger Campbell, MD: Neuroscience for Everyone
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