395 —  Dr. Nathan Bryan: Hormones, Heart & Skin—Surprising Roles for Nitric Oxide

395 — Dr. Nathan Bryan: Hormones, Heart & Skin—Surprising Roles for Nitric Oxide

Author: Doctor Podcast Network October 2, 2025 Duration: 1:14:00

Molecular-medicine expert Dr. Nathan Bryan explains how nitric oxide (NO) protects the endothelium, drives vasodilation, and influences energy, immunity, hormones, and longevity. He links stubborn hypertension and poor exercise tolerance to the microbiome–NO axis and outlines common NO killers—antiseptic mouthwashes and fluoride overuse, chronic PPIs, ultra-processed diets, and inactivity. We cover practical restores (movement, nutrient-dense food, targeted micronutrients, careful PPI weaning, ditching antiseptic rinses) and preview clinical work on NO-releasing lozenges for ischemic heart disease, approaches to improve cerebral blood flow and insulin signaling in cognitive decline, and topical NO for chronic wounds. Bryan also touches on food quality (glyphosate, soil health), hormone synergy with NO, and NO-based skincare that supports perfusion and collagen. Bottom line: rebuild NO, and the body’s own repair systems can finally do their job.

(Educational only; not personal medical advice.)

Guest Bio

Nathan S. Bryan, PhD is a molecular medicine researcher and leading authority on nitric oxide (NO) biochemistry. Over two decades, he has mapped how the body generates and uses NO—and what happens when it doesn’t—publishing widely, authoring multiple books, and translating discoveries into products and late-stage drug trials. His work spans cardiovascular health, metabolism, neurocognition, wound healing, and skin biology, with a focus on restoring NO as a foundation for repair. Dr. Bryan speaks globally on NO and leads development of NO-based therapeutics targeting ischemic heart disease, Alzheimer’s disease, and non-healing ulcers.
 

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Everything in this podcast is for educational purposes only. It does not constitute the practice of medicine and we are not providing medical advice. No Physician-patient relationship is formed and anything discussed in this podcast does not represent the views of our employers. 

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All opinions expressed by the hosts or  guests in this episode are solely their opinion and are not to be used as specific medical advice.  The hosts,  May and Tim Hindmarsh MD, BS Free MD LLC, or any affiliates thereof are not under any obligation to update or correct any information provided in this episode. The guest's statements and opinions are subject to change without notice.

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Tired of the same old medical talk that feels disconnected from real life? BS Free MD with Drs. May and Tim Hindmarsh offers something different. This is a conversation between two practicing physicians who are also partners, blending their professional expertise with personal experience. Each episode feels like pulling up a chair at their kitchen table, where discussions about healthcare, medical history, and philosophy are grounded in the realities of life, family, and the daily grind of being a doctor. You'll hear honest reflections on the system, stories from the front lines that you won't find in textbooks, and a genuine look at how medicine intersects with everything else. The Doctor Podcast Network brings you this unique perspective, where the dialogue is as engaging as it is insightful. It’s a space for anyone curious about the human side of medicine-patients and professionals alike. This podcast doesn’t shy away from complex topics, but it approaches them with a warmth and authenticity that makes even the heaviest subjects feel accessible. Expect candid stories, occasional tangents into culture and society, and the shared wisdom of two people who see the world through both a stethoscope and a shared life. Tune in for a genuinely fresh take.
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