Your Brain's Silent War: Dr. David Perlmutter on the Immune Cells That Make or Break Your Mind

Your Brain's Silent War: Dr. David Perlmutter on the Immune Cells That Make or Break Your Mind

Author: Dr Daniel & Tana Amen August 17, 2026 Duration: 54:01
For decades, medicine has treated memory loss, brain fog, and neurodegenerative disease as inevitable — but what if the real battle is happening at the cellular level, inside your brain's own immune system? In this episode, six-time New York Times bestselling author and neurologist Dr. David Perlmutter joins Dr. Amen & Tana to unpack the findings from his groundbreaking new book, Brain Defenders. We explore microglia — the brain's immune cells that can act as either warriors of protection or agents of destruction, depending on how we live. Dr. Perlmutter breaks down the overlooked role of inflammation in conditions ranging from dementia to long COVID and lays out practical, evidence-based strategies to counter threats such as poor diet, environmental toxins, and lack of restorative sleep. If you've ever wondered whether cognitive decline is truly inevitable — or whether you have more control over your brain's future than you think — this conversation will change how you think about aging, disease, and prevention.
 
Purchase Brain Defenders: https://a.co/d/00qR4E3Y

What if the small, daily decisions you make about food, thought patterns, and lifestyle are actively shaping your biology for better or worse? That’s the central exploration you’ll find within Change Your Brain Every Day, a conversation hosted by Dr. Daniel Amen and Tana Amen. Moving beyond theory, this podcast delivers practical, actionable strategies rooted in clinical experience. Each episode feels like a direct consultation, where the Amens translate complex neuroscience into clear steps anyone can use. You’ll hear them discuss how specific habits influence conditions like anxiety, focus, and low mood, offering a tangible sense of agency over your own mental and physical well-being. The tone is both authoritative and deeply encouraging, stripping away the overwhelm that often accompanies health advice. Rather than promising a single miracle cure, the focus is on sustainable, incremental change-the kind that compounds over weeks and months to create lasting results. Tuning into this podcast is an investment in understanding the direct connection between your daily life and your brain’s health. It’s for anyone who feels stuck in unhelpful cycles or is simply curious about optimizing their mind. The Amens act as guides, providing the tools to not just manage symptoms, but to fundamentally reshape your approach to your own health journey, one day at a time.
Author: Language: English Episodes: 50

Change Your Brain Every Day
Podcast Episodes
Dr. Daniel Amen's: 11 Simple Food Rules for a Healthy Brain & Body [not-audio_url] [/not-audio_url]

Duration: 46:40
Food is medicine, or it's poison. Knowing what to eat and having the discipline to stick to the plan are usually the biggest game-changers for improving the health of both your body and your brain. In this video, Dr. Ame…
Hijacked Brains: The Science of Addiction and How to Heal [not-audio_url] [/not-audio_url]

Duration: 57:43
On this episode of Change Your Brain Every Day, host Dr. Daniel Amen sits down with renowned addiction expert Mark Gold for a powerful, eye-opening conversation about addiction—and why it has far more to do with brain he…
What Brings Out Judgmental Tendencies in People? [not-audio_url] [/not-audio_url]

Duration: 47:51
Responsibility is one of Tana's favorite words because it's a word that helped her get through a difficult time in her life. However, many people tend to confuse the word 'responsibility' with 'blame', which can lead to…
Tarek El Moussa: Extreme Makeover Brain Health Edition [not-audio_url] [/not-audio_url]

Duration: 42:53
On this week's episode of Change Your Brain Every Day, Dr. Amen sits down with real estate investor and TV personality Tarek El Moussa. Tarek came to see Dr. Amen 1-year ago and his brain was struggling. This episode is…
A Psychiatrist's Tips for Teaching Children Problem Solving Skills [not-audio_url] [/not-audio_url]

Duration: 5:29
As parents, we often care so much about our children's well-being that we will do whatever we can to make things easier for them. However, when we step in to fix our children's problems, are we helping them or hurting th…
EMDR: Getting Over Past Trauma for Good [not-audio_url] [/not-audio_url]

Duration: 47:13
This in throwback episode, Dr. Amen and Tana Amen first began their relationship, Tana was carrying past trauma from her past experiences. Daniel suggested a unique treatment method for getting over trauma, but Tana wasn…