A Sublingual Solution

A Sublingual Solution

Author: Children's Hospital Colorado January 28, 2025 Duration: 44:12

Anaphylaxis is a serious, systemic hypersensitivity reaction with rapid onset and can be potentially fatal. It is frightening for patients, families and medical providers. Currently, the standard treatment is epinephrine as an injection. At this very moment, we are on the cusp of transforming how we treat severe allergic reactions. If approved by the FDA, a new sublingual form of epinephrine would be the first non-invasive and orally administered epinephrine treatment.

Joining us for this episode is Matthew Greenhawt, MD, the Director of the Food Challenge and Research Unit at Children's Hospital Colorado. He specializes in allergy and immunology and is also a professor of pediatrics at the University of Colorado School of Medicine.  

Some highlights from this episode include: 

  • The history of epinephrine 
  • Fears around needles and using an epi-pen 
  • How this new treatment could increase the life-saving capability of epinephrine 
  • Next steps to get the sublingual film into use 

For more information on Children's Colorado, visit: childrenscolorado.org. 


For those dedicated to the health of children, Charting Pediatrics serves as a vital, ongoing conversation directly from the front lines of pediatric care. Produced by the multidisciplinary experts at Children's Hospital Colorado, this weekly podcast delves into the nuanced realities of modern medicine for young patients. Each episode moves beyond textbook summaries to explore the practical application of groundbreaking research, emerging innovations, and essential educational resources. The discussions are candid, often tackling the complex challenges that clinicians face daily, from evolving treatment protocols to systemic issues within the healthcare community. Now in its eighth season, the program has established itself as a trusted source for physicians, nurses, and allied health professionals seeking to deepen their knowledge and refine their practice. Listening to this podcast feels like gaining direct access to a roundtable of specialists, all focused on a single goal: empowering medical providers with the context and confidence needed to make the best decisions for their patients. The tone is collegial and insightful, transforming the latest evidence and clinical experience into actionable understanding. It’s where the science of pediatrics meets the art of its application, fostering a supportive dialogue for anyone committed to advancing child health.
Author: Language: English Episodes: 100

Charting Pediatrics
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