Dead Mitochondria Might Be Fueling Cardiovascular Aging — Here’s The Fix

Dead Mitochondria Might Be Fueling Cardiovascular Aging — Here’s The Fix

Author: Dr. Kara Fitzgerald July 8, 2025 Duration: 47:27
This is a really exciting conversation with Dr. Davide D’Amico from Timeline, where we’re taking a closer look at Urolithin A and heart health. It should come as no surprise that this mitochondrial wonderkin of a nutrient is showing promise here—especially when you consider that 40% of the heart’s weight is mitochondria. That’s an extraordinary factoid, and one that really shifts how we think about aging in the cardiovascular system.

What’s particularly compelling in this new preclinical research is that restoring mitochondrial function may do more than just improve ejection fraction. It may also have ripple effects on other hallmarks of aging—like chronic inflammation, cellular stress signaling, and impaired autophagy. I’m thrilled Timeline is continuing to invest in both preclinical and clinical research on this front—and yes, I’m totally nerding out over what they’re up to. ~DrK

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS Davide D'Amico, PhD: Director of Discovery and Translational Research at Timeline.

With over 15 years of experience in mitochondrial and aging biology, he contributed to developing Urolithin A as a science-backed, clinically validated nutritional product to enhance mitochondrial and muscle health.

THANKS TO OUR SPONSOR

Timeline: http://Timeline.com/kara10

Email: care@timeline.com

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Mitopure is making impressive strides for cellular health and longevity. Get 10% off your first order at http://Timeline.com/kara10 with code Kara10.

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In each episode of Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics, host Dr. Kara Fitzgerald sits down with leading researchers and clinicians to explore the intricate science that is reshaping our approach to health. These conversations move beyond surface-level advice, digging into the mechanisms of epigenetics and the practical strategies for extending healthspan. You’ll hear detailed discussions on emerging research, with a focus on how our environment and choices influence genetic expression over a lifetime. This podcast is designed for anyone curious about the actionable science behind longevity, from healthcare practitioners seeking clinical insights to informed patients ready to engage deeply with their own wellness. The dialogue is grounded in functional medicine principles, translating complex studies into meaningful information that can be applied both in clinical settings and daily life. Dr. Fitzgerald guides these explorations with a clear and thoughtful perspective, ensuring each episode builds a comprehensive understanding of how modern science is personalizing the path to lasting health. Tune in for a nuanced and evidence-based journey to the forefront of medicine.
Author: Language: English Episodes: 100

Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics
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