This GLP-1-Supporting Probiotic Is A Constant In Our Longevity Stack
Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the first place. Plus, we’ll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We’ll also dive into the hotly debated topic of Akkermansia’s impact on MS, unpacking both sides of the controversy. And, we’ll touch on its promising influence on hormonal balance, from infertility to menopause.
As someone who's deeply invested in science, I’m personally bullish on Akkermansia and trust Pendulum’s products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Colleen Cutcliffe, PhD, Co-Founder and CEO of Pendulum Therapeutics Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.THANKS TO OUR SPONSOR
Pendulum: https://tinyurl.com/hzbxh75f
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CONNECT WITH DrKF
In each episode of Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics, host Dr. Kara Fitzgerald sits down with leading researchers and clinicians to explore the intricate science that is reshaping our approach to health. These conversations move beyond surface-level advice, digging into the mechanisms of epigenetics and the practical strategies for extending healthspan. You’ll hear detailed discussions on emerging research, with a focus on how our environment and choices influence genetic expression over a lifetime. This podcast is designed for anyone curious about the actionable science behind longevity, from healthcare practitioners seeking clinical insights to informed patients ready to engage deeply with their own wellness. The dialogue is grounded in functional medicine principles, translating complex studies into meaningful information that can be applied both in clinical settings and daily life. Dr. Fitzgerald guides these explorations with a clear and thoughtful perspective, ensuring each episode builds a comprehensive understanding of how modern science is personalizing the path to lasting health. Tune in for a nuanced and evidence-based journey to the forefront of medicine.
Podcast Episodes
From Hot Flashes to Healthspan: The FxMed Guide to Hormones & Longevity
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with hormone and women’s health expert Dr. Carrie Jones to explore the powerful connection between mitochondrial health and women’s h…
Guide to Building a Sustainable Concierge Longevity Practice
Dr. Kara Fitzgerald sits down with Dr. Brooke Stubbs, an internal and lifestyle medicine physician who transitioned from hospital medicine to a concierge model focused on prevention and personalization. Together, they di…
Reversing Aging: Screening, Wearables & What To Do Now
Dr. Kara Fitzgerald talks with Sergey Young, founder of the Longevity Vision Fund and XPRIZE board member, about the future of aging medicine. Hear how AI, wearables, new diagnostics, and early screening are making longe…
Aging & Hair Loss Explained: OS-01’s Science-Backed Approach
Hair loss is more than cosmetic. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald explores new research on the OS-01 peptide and its role in targeting senescent cells. Learn how peptide therap…
The Bile Acid Imbalance Accelerating Aging: How to Detect & Fix It
Have you ever struggled to understand why some patients just don’t respond as expected, even when you’re following all the usual gut protocols? In this episode, I sat down with Dr. Tom Fabian, who breaks down the latest…
Why Functional Medicine Is the Future of Longevity
Can functional medicine unlock the secrets to healthy aging? In this special preview of the Functional Medicine is Longevity Medicine™ Masterclass happening on September 17- September 19, 2025, Dr. Kara Fitzgerald sits d…
Why Centenarians Are Defying Science: Secrets to Living 100+
It was a pleasure to sit down with Dr. Nir Barzilai for a conversation that turned out to be both lively and thought-provoking. His decades of research on centenarians, biological age, and the hallmarks of aging have sha…
The Science-Backed Bitter Compound That Mimics GLP-1 (No Injections Needed!)
I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compo…
10 Year Anniversary: What I Learned After 200+ Conversations with the Best Minds in FxMed
In this very special episode, I have the privilege of turning the tables on Dr. Kara Fitzgerald as we celebrate 10 years of the New Frontiers podcast. I’ve been honored to walk alongside Kara on much of this journey—as a…
Dead Mitochondria Might Be Fueling Cardiovascular Aging — Here’s The Fix
This is a really exciting conversation with Dr. Davide D’Amico from Timeline, where we’re taking a closer look at Urolithin A and heart health. It should come as no surprise that this mitochondrial wonderkin of a nutrien…