ENP112: Osteoporosis and the SABRE Project

ENP112: Osteoporosis and the SABRE Project

Author: Endocrine Society May 18, 2026 Duration: 24:00

The U.S. Food and Drug Administration recently qualified "total hip bone mineral density" as a surrogate endpoint to support clinical trials for osteoporosis drugs. This decision will significantly impact clinical trials moving forward, as the traditional endpoint of "fracture outcomes" presented many challenges regarding sample size, duration, and cost.

The change came about because of findings from the study to advance bone mineral density as a Regulatory Endpoint Project, also known as the SABRE project.

What is the SABRE project, and how did it arrive at these findings? How will this decision affect the design of clinical trials and time to approval of new osteoporosis therapies?

To help answer these questions and many more, Host Aaron Lohr spoke with three leaders of the SABRE Project: Dennis M. Black, PhD, professor of epidemiology and biostatistics at the University of California, San Francisco; Richard Eastell, MBChB, PhD, FRCP, FMedSci, professor of bone metabolism at the University of Sheffield, and Mary L. Bouxsein, PhD, professor of orthopedic surgery at Harvard Medical School.


Ever wondered how the latest scientific discoveries actually translate to patient care or what drives the decisions of leading clinicians and researchers? The Endocrine News Podcast, produced by the Endocrine Society, sits down with those very experts to pull back the curtain on a rapidly evolving field. Each conversation goes beyond the headlines of journal articles, exploring the real-world implications of new findings in diabetes, thyroid disorders, hormone-related cancers, and countless other conditions. You’ll hear researchers explain the nuance behind their data, clinicians debate emerging treatment protocols, and thought leaders outline where the science is headed next. This isn't a dry lecture; it's a direct line to the people shaping modern endocrinology. The discussions are grounded and accessible, designed for anyone with a professional or deep personal interest in hormonal health. Whether you're a practicing physician, a trainee, a dedicated patient advocate, or simply fascinated by how the body's intricate systems work, this podcast offers substantive insights. Tuning in provides a unique way to stay current with the trends and controversies that define the specialty today. The entire archive is a free resource, reflecting the Society's mission to advance endocrine science and public understanding. Suggestions for future topics are always welcome, keeping the dialogue connected to the community's most pressing questions.
Author: Language: English Episodes: 50

Endocrine News Podcast
Podcast Episodes
ENP75: A Case Study on Fungal Sinusitis in T2D [not-audio_url] [/not-audio_url]

Duration: 14:28
From ENDO 2023, host Aaron Lohr talks with Jayalakshmi Udayasankar, MD, from the Palo Alto Medical Foundation, about her team’s research presented at the meeting, titled, “Tingling Over Cheek: An Atypical Presentation of…
ENP74: Healthy and Unhealthy Obesity [not-audio_url] [/not-audio_url]

Duration: 11:26
In another dispatch from ENDO 2023, host Aaron Lohr talks with Max Petersen, MD, PhD, from Washington University in St. Louis, about his team’s research presented at the meeting. Their presentation was titled, “Cellular…
ENP73: A Robotic Teriparatide Pill to Treat Osteoporosis [not-audio_url] [/not-audio_url]

Duration: 10:43
Host Aaron Lohr talks with two researchers at ENDO 2023, Kyle Horlen, DVM, and Joshua Myers, both from Rani Therapeutics, about two presentations they made about an oral treatment of teriparatide for the treatment of ost…
ENP72: GHR, Insulin, and Life Span [not-audio_url] [/not-audio_url]

Duration: 22:35
In another interview from ENDO 2023, host Aaron Lohr talks with Silvana Duran Ortiz, Ph.D., a postdoctoral research fellow at Ohio University, about her team’s research presented at the meeting. Their presentation was ti…
ENP70: Hormones and Aging [not-audio_url] [/not-audio_url]

Duration: 12:41
Whether we like it or not, we’re all getting older. What do we know about how aging impacts our endocrine system? What don’t we know? That’s what we’re here to talk about today, as we look at the new scientific statement…
ENP69: Biosimilar Insulin [not-audio_url] [/not-audio_url]

Duration: 16:27
In this episode, we hear about biosimilar insulin: its safety, efficacy, what sets it apart from biologic insulin, and when it should be considered for use. Host Aaron Lohr talks with Irl Hirsch, MD, professor of medicin…
ENP68: Hypercalcemia of Malignancy [not-audio_url] [/not-audio_url]

Duration: 14:33
Recently the Endocrine Society published a new clinical practice guideline entitled, “Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.” What exactly is hypercalcemia o…
ENP67: Growth Hormone Deficiency [not-audio_url] [/not-audio_url]

Duration: 19:47
In this episode, host Aaron Lohr discusses screening, diagnosis, and current and emerging treatment options for the long-term management of growth hormone deficiency in pediatric and adult patients with Dr. Mark E. Molit…