Ep. 557 “Your Hormones Are Hijacking Your Mood!” – The Shocking Way to Reduce Anxiety, Depression & Insomnia in Perimenopause

Ep. 557 “Your Hormones Are Hijacking Your Mood!” – The Shocking Way to Reduce Anxiety, Depression & Insomnia in Perimenopause

Author: Everyday Wellness™ February 19, 2026 Duration: 20:12
Welcome to this week’s Midlife Minute episode. We’re focusing on the importance of having good mental health today. Statistics show that women are experiencing increased anxiety, depression, insomnia, and even suicidal thoughts during midlife, yet the stigma around mental health remains surprisingly strong. Join me as I explore the science behind this, why it’s happening, and the importance of empowering yourself to demand better care. IN THIS EPISODE, YOU WILL LEARN: The issues that contribute to the midlife mental health challenges women are experiencing How sleep disruptions in perimenopause increase anxiety, depression, and irritability The metabolic and endocrine factors that can compound mood instability in midlife Why perimenopause is a neurological as well as reproductive transition The evidence-based benefits of HRT for supporting mental health The role of estrogen in brain function and emotional regulation Why HRT is especially important for women experiencing abrupt or early menopause Some practical guidance for using HRT to support mental health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line References: Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial (https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2298235)  Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers (https://onlinelibrary.wiley.com/doi/10.1002/da.22391) Effects of Hormone Therapy on Cognition and Mood (https://www.fertstert.org/article/S0015-0282(14)00178-2/fulltext) Does Menopause Hormone Therapy Improve Symptoms of Depression? Findings From a Specialized Menopause Clinic  A Meta-analysis of the Effect of Hormone Replacement Therapy upon Depressed Mood (https://www.sciencedirect.com/science/article/abs/pii/S0306453096000340?via%3Dihub) The Effect of Hormone Replacement Therapy on Cognition and Mood (https://onlinelibrary.wiley.com/doi/10.1111/cen.14856)

Navigating the changes that come with midlife can feel isolating, but it doesn't have to be a solo journey. Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+ is a conversation grounded in evidence and empathy. Host Cynthia Thurlow brings her perspective as a nurse practitioner and a woman in this life stage, translating complex science into practical strategies. With over 25 years in health and wellness, including a widely-viewed TEDx talk on intermittent fasting, she connects the dots between hormones, metabolism, and long-term vitality. This podcast delves into the nuanced realities of perimenopause and beyond, moving past generic advice to explore personalized nutrition, sustainable fitness for changing bodies, and managing sleep and stress. It’s a resource for anyone seeking to understand the *why* behind their symptoms and find actionable steps that fit into a real, busy life. The discussions are direct, informed by the latest research, and focused on empowering women to advocate for their own health. Tune in for honest dialogues that replace confusion with clarity and foster a sense of community around shared experiences.
Author: Language: English Episodes: 100

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+
Podcast Episodes