270. Leslie Kenny on Optimizing Fertility, Healthy Aging, Reversing Biological Age, and the Hidden Power of Spermidine [Part 2]

In this episode, longevity expert and autoimmune survivor Leslie Kenny returns to share how she reversed her biological age to 21, despite being almost 60 years old. From overcoming lupus and rheumatoid arthritis to naturally conceiving at 42 after years of infertility, Leslie’s journey is nothing short of extraordinary.

We dive deep into the science of healthy aging, fertility, and spermidine—a natural compound with incredible anti-aging and cellular renewal benefits, plus other hidden benefits. Leslie breaks down how to reduce inflammation, balance hormones, and optimize your health using cutting-edge yet natural tools. Whether you're in your 30s thinking about fertility or in your 50s thinking about vitality, this episode is packed with real talk, research, and inspiration you don’t want to miss.

About Leslie Kenny:

Leslie Kenny is a wellness entrepreneur, certified health coach, and founder of Oxford Healthspan, the first company to bring food-derived spermidine to the U.S. market. After being told she had just five years to live following a diagnosis of lupus and rheumatoid arthritis at age 39, Leslie took her health into her own hands and changed the course of her life. Today, she’s a thriving patient advocate, biohacker, and longevity leader based in Oxford, UK.

— Episode Chapter Big Ideas (timing may not be exact) —

0:00 – Intro

0:37 – Leslie’s TEDx talk experience and life in Oxford

3:22 – Vitamin D, light exposure & why it matters for longevity

5:23 – Sunlight, cortisol, ghrelin & how light helps you lose weight

8:11 – Astaxanthin, supplements for sun protection, and light sensitivity

10:51 – Leslie’s backstory: lupus, RA, 5 failed IVFs, and her journey to healing

20:34 – The myth of “inevitable decline” and breaking medical predictions

25:40 – Conceiving naturally at 42 after being told she couldn’t

30:06 – Signs of thyroid dysfunction doctors often miss

33:05 – Spermidine for egg quality, sperm health & embryogenesis

37:28 – How to take spermidine: timing, food sources, and safety tips

40:37 – Dangers of synthetic spermidine and benefits of food-derived forms

46:21 – The 12 hallmarks of aging & how spermidine addresses 9 of them

49:06 – What space travel teaches us about accelerated aging

54:04 – Leslie’s protocol for maintaining a biological age of 21

58:13 – Why fasting doesn’t work for all women

1:03:25 – Leslie’s 5 health tips for optimizing fertility

1:06:20 – How to bookend your fasting window with spermidine

1:07:30 – Where to find Leslie online & what’s next for her

— Key Quotes from Leslie Kenny — 

"You are not your diagnosis. And never accept that."

"Your body is a miracle. There is so much more you can do. You are underestimated."

"If the environment is safe, the body will allow life. If it’s not, it shuts everything down — including fertility."

— Connect With Leslie Kenny —

Learn more about spermidine: https://oxfordhealthspan.com

The Oxford Longevity Project: https://oxfordlongevityproject.org

Leslie’s speaking & personal site: https://lesliesnewprime.com

Follow Leslie on Instagram: https://www.instagram.com/lesliesnewprime

Listen to Part 1 (recommended if you missed it!): https://youtu.be/bULNOEvuxms or https://open.spotify.com/episode/2i0NmcWE553uoHPbhka0Kw?si=43702b56e67d4db1

Use the code JULIAN15 to save 15% off your first purchase: ⁠https://oxfordhealthspan.com/collections/all-products

— Connect with Julian and Executive Health —

LinkedIn — https://www.linkedin.com/in/julianhayesii/

Ready to take your health, leadership, and performance to the next level? Book a complimentary private executive health diagnostic call with Julian Hayes II. Link below. https://calendly.com/julian-exechealth/chemistry

Website — https://www.executivehealth.io/

***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner.