013 The Zero Dollar Genome

013 The Zero Dollar Genome

Author: The Genetics Society May 9, 2019 Duration: 34:01

The first draft of the human genome came with a price tag running into billions of dollars. In less than twenty years, the cost of whole genome sequencing had plummeted, making the thousand dollar genome a reality by 2014, and opening up a consumer market for personal genome sequencing - although as geneticist Elaine Mardis quipped, it’s a $1000 genome, and a £100,000 analysis. The price for sequencing continues to fall, and several companies are vying to be the first to break the hundred dollar barrier.

But, according to George Church, professor of genetics at Harvard Medical School and one of the world’s leading authorities on genes and genomes, we’re about to see the dawn of the zero dollar genome, making personal whole genome sequencing effectively free in exchange for the data.

We also chat with genomics researcher Manuel Corpas about how his experience of personal genome sequencing became very personal once he got his whole family involved, particularly when everyone started competing to see who had the 'best' genes.

Genetics Unzipped is written and presented by Kat Arney, and produced by First Create the Media for the Genetics Society - one of the oldest learned societies in the world dedicated to supporting and promoting the research, teaching and application of genetics. Production by Hannah Varrall.

Full show notes and links available at https://geneticsunzipped.com/blog/2019/5/9/the-zero-dollar-genome


Ever wondered how a monk's garden peas changed science, or what your own DNA might reveal about you? Genetics Unzipped, presented by The Genetics Society, explores these questions and countless others, weaving together the past, present, and future of heredity. This isn't a dry lecture series; it's a collection of conversations and narratives that make the complex world of genes feel immediate and fascinating. Each episode delves into a specific story, whether it's a historical breakthrough, a debate in modern medicine, or the surprising genetic connections in nature and our daily lives. You'll hear from researchers, historians, and sometimes the subjects of genetics themselves, all unpacking how DNA shapes health, fitness, evolution, and what it means to be alive. The podcast moves seamlessly from the fundamentals to the frontiers, making the science accessible without oversimplifying the profound implications. Tune in for a thoughtful and engaging exploration that goes far beyond the helix, examining the very code that writes our stories.
Author: Language: English Episodes: 168

Genetics Unzipped
Podcast Episodes
S6.27: Next Generation Sequence: Forging new paths in genetics [not-audio_url] [/not-audio_url]

Duration: 37:30
Please fill out our listener survey at geneticsunzipped.com/survey before January 31stThis episode is all about the next generation, as we meet three up-and-coming scientists who have been supported by the Genetics Socie…
S6.26: The battle for biology: How Mendel came to rule the world [not-audio_url] [/not-audio_url]

Duration: 42:54
Please take a minute or two to fill out our listener survey and help shape the future of the podcast: https://geneticsunzipped.com/surveyIn this episode, we talk to Greg Radick from the University of Leeds to explore the…
S6.25: 2023 Unzipped [not-audio_url] [/not-audio_url]

Duration: 35:38
Please take a minute or two to fill out our listener survey and help shape the future of the podcast: https://geneticsunzipped.com/surveyAs 2023 draws to a close, we’re bringing you a smorgasbord of previously unaired cl…
S6.24: Genes, junk and the ‘dark genome’ [not-audio_url] [/not-audio_url]

Duration: 37:31
Please take a minute or two to fill out our listener survey and help shape the future of the podcast: https://geneticsunzipped.com/surveyWe discover how 500,000 whole genome from UK Biobank will help medical research, pl…
S6.23: 40 years of HIV: the disease that broke the rules [not-audio_url] [/not-audio_url]

Duration: 35:12
Please take a minute or two to fill out our listener survey and help shape the future of the podcast: https://geneticsunzipped.com/surveyWith 2023 marking 40 years since the discovery of HIV, we're looking back over four…
S6.22: Dumb luck: Amazing adaptations from happy little accidents [not-audio_url] [/not-audio_url]

Duration: 29:15
Author and science journalist Rebecca Coffey chats with us about some amazing adaptations and Darwinian delights from her book, Beyond Primates. She tells us about wasp facial recognition genes, how yeast epigenetics exp…
S6.21: Time of your life: how circadian rhythms shape the world [not-audio_url] [/not-audio_url]

Duration: 0:00
In this episode we’re clocking in to chat about the genetics of circadian rhythms. How can molecules tell the time, why don’t we have drugs for jet lag yet and could a midnight snack stop malaria in its tracks?Full show…
S6.19: Food for the future: Helping plants adapt to a changing world [not-audio_url] [/not-audio_url]

Duration: 44:29
We’re finding out how plants adapt to a changing environment, and how we might be able to give them a helping hand so that we can keep feeding the world sustainably in the future. Full show notes, transcript and referenc…
BONUS Hormones: The Inside Story - Is my diabetes my fault? [not-audio_url] [/not-audio_url]

Duration: 40:18
In this bonus episode, we’re bringing you the third instalment of Hormones: The Inside Story, Season 3. This podcast is produced for the Society for Endocrinology by the same team behind Genetics Unzipped. Find it on Pod…