Psilocybin in Serious Illness: A Podcast with James Downar, Ali John Zarrabi and Margaret Ross

Psilocybin in Serious Illness: A Podcast with James Downar, Ali John Zarrabi and Margaret Ross

Author: Alex Smith, Eric Widera May 8, 2025 Duration: 46:57

We've covered psychedelics on the podcast before—first in 2019 with Ira Byock, where we explored their potential role in medicine, and then again in 2023 with Stacy Fischer, Brian Anderson, and Theora Cimino, focusing on the reasons to approach psychedelic use in patients with caution.

In today's episode, we're taking a closer look at the current state of the science around one specific psychedelic: psilocybin. We'll discuss three recent clinical trials involving patients with serious illness, joined by our guests James Downar, Ali John Zarrabi, and Margaret Ross

We begin with a refresher on psilocybin—what it is, how it might work, what conditions it may help treat (including demoralization), and how it's typically administered. What makes this episode especially compelling is our deep dive into the three studies, which highlight two different approaches to using psilocybin: daily microdosing, similar to traditional antidepressants, and a more intensive model known as psilocybin-assisted therapy. This latter approach involves three structured phases—preparation, the dosing session, and post-session integration with trained therapists.







Hosted by UCSF physicians Alex Smith and Eric Widera, GeriPal-A Geriatrics and Palliative Medicine Podcast creates a vital space for conversation at the intersection of aging and serious illness care. This isn't a dry lecture series; it's a dynamic dialogue where Eric and Alex bring on leading experts to unpack the complexities of geriatric and palliative medicine. They delve into the latest research that should change practice, tackle the ethical dilemmas that provoke debate, and explore the nuanced clinical challenges that professionals face daily. The tone is engaging and often surprisingly lighthearted, with moments of humor and even the occasional song, making profound topics more accessible. Whether you're a clinician, nurse, social worker, or any professional dedicated to this field, this podcast offers a blend of evidence-based insights and practical wisdom you can use. It’s a resource that acknowledges the weight of the work while fostering connection and continued learning. For those seeking formal education credits, AMA PRA Category 1 CME and MOC credit are also available through the show. Tune in to join a community committed to improving care for older adults and those with serious illness.
Author: Language: English Episodes: 100

GeriPal - A Geriatrics and Palliative Medicine Podcast
Podcast Episodes
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HIV, Aging, and Palliative Care: Peter Selwyn and Meredith Greene [not-audio_url] [/not-audio_url]

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I read Farah Stockman's article in the NYT on why attacks on DEI will cost us all, and thought, "Yes, and 'everyone' includes harm to our healthcare workforce, our patients, and their families." So we're delighted that F…
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Duration: 50:34
Early in my research career, I was fascinated by the (then) frontier area of palliative care in the emergency department. I asked emergency medicine clinicians what they thought when a patient who is seriously ill and DN…