Ep 113: A 62-Year-Old with Pruritis

Ep 113: A 62-Year-Old with Pruritis

Author: AccessMedicine January 11, 2024 Duration: 8:25

Learn more about this in Chapter 355: Cirrhosis and Its Complications

In this episode of Harrison's Podclass, Dr. Cathy Handy and Dr. Charlie Wiener tackle the case of a 62-year-old woman presenting with pruritus and a constellation of symptoms including fatigue, weight loss, and intermittent nausea. The discussion delves into the diagnostic process, highlighting key clinical findings such as jaundice, spider angiomata, and a nodular liver.

Dr. Handy and Dr. Wiener explore the implications of these findings, focusing on the differential diagnosis for cirrhosis and the potential underlying causes. The episode emphasizes the significance of antimitochondrial antibodies (AMA) in diagnosing primary biliary cholangitis (PBC), a condition characterized by chronic liver inflammation and bile duct destruction.

Listeners will gain insights into the histopathology of PBC, typical laboratory findings, and the treatment options available, including the role of Ursodeoxycholic acid and liver transplantation. The episode concludes with a brief review of alternative diagnostic tests and their relevance in the broader context of liver disease.

Tune in for a comprehensive discussion on diagnosing and managing liver conditions in an older adult, with practical insights for clinicians dealing with similar cases.

Harrison's Principles of Internal Medicine, 22nd Edition


Dive deep into the complex world of clinical practice with Harrison's PodClass: Internal Medicine Cases and Board Prep. This isn't just another medical review; it's a dynamic conversation that brings textbook principles to life. Guided by the expert perspectives of Drs. Cathy Handy Marshall and Charlie Wiener from The Johns Hopkins School of Medicine, each episode unpacks real-world diagnostic puzzles and management strategies. The discussions are built directly from the authoritative material found in Harrison's Review Questions and the seminal Harrison's Principles of Internal Medicine, making this podcast an invaluable companion for serious study. Whether you're a resident navigating your clinical years, a physician preparing for board certification, or a student seeking to solidify foundational knowledge, these conversations translate dense material into relatable, engaging clinical narratives. You'll hear thoughtful analysis of board-style vignettes, where the hosts break down the reasoning behind each diagnosis and therapeutic decision, moving beyond memorization to true comprehension. Produced by McGraw Hill's AccessMedicine, this series connects the dots between theory and practice, offering a portable, audio-based layer to your medical education. Tune in to refine your clinical thinking, stay current on key topics, and find a more nuanced understanding of internal medicine through the detailed, case-driven dialogue that defines this resource.
Author: Language: English Episodes: 189

Harrison's PodClass: Internal Medicine Cases and Board Prep
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