Insulin Resistance Fuels Artery-Clogging Plaque, Early Atherosclerosis

Insulin Resistance Fuels Artery-Clogging Plaque, Early Atherosclerosis

Author: Mike Mutzel shares interviews with Peter Attia, Jason Fung, Stan Efferding, May 25, 2024 Duration: 14:27

A new study finds insulin resistance and reduced glucose uptake in the heart is linked with early-onset atherosclerosis and heart issues.

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Link to Video and Research: https://bit.ly/3UXLhal

Research Mentioned:

Devesa, A. et al. Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis. Diabetes Care 46, 2050–2057 (2023).

Time Stamps:

00:00 FDG = Fluorodeoxyglucose

00:30 Reduced glucose uptake in the heart is tethered to atherosclerosis.

01:20 LDL levels are not strongly associated with poor outcomes.

02:00 Your heart becomes insulin resistant.

03:05 Those with no glucose uptake in the heart had higher fasting glucose.

03:45 Those with more cardiovascular risk factors had lower LDL.

04:35 The heart can generate energy from fatty acids, carbs, and ketones.

05:00 Cardiac abnormalities are associated with metabolic syndrome.

07:00 Insulin resistance changes muscle and heart muscle.

09:16 Insulin resistance is associated with a progressive decrease of myocardial FDG uptake.

09:50 Cardiovascular risk increases with the decline of FDG uptake.

11:30 Your heart loses the ability to pump blood effectively as it loses ability to utilize different energy substrates.

12:40 Support your heart by supporting your metabolism.


Tune into High Intensity Health with Mike Mutzel, MS for conversations that cut through the noise of mainstream wellness trends. Host Mike Mutzel, who holds a Master of Science degree, sits down with leading researchers and practitioners like Peter Attia, Jason Fung, and Stan Efferding to explore the science behind lasting health. This podcast delves into the interconnected systems of the human body, moving beyond simplistic advice to discuss metabolic flexibility, gut health, and immune function with a level of detail you won't find everywhere. Each episode is a deep dive, whether the topic is nutritional strategies for reducing body fat, protocols for enhancing mental clarity, or training principles for elite athletic performance. The dialogue is grounded in functional medicine and evidence-based practices, offering actionable insights rather than just theory. Listeners gain access to the nuanced, often insider perspectives that these experts share with their own clients and patients. It’s for anyone-parents, professionals, clinicians, or athletes-who wants to understand the *why* behind their health decisions and take a more strategic approach to their own well-being. You'll finish an episode of this podcast not just with tips, but with a clearer framework for making informed choices about nutrition, fitness, and overall longevity.
Author: Language: English Episodes: 100

High Intensity Health with Mike Mutzel, MS
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