Bacteriophages

Bacteriophages

Author: BBC Radio 4 August 1, 2024 Duration: 50:43

Melvyn Bragg and guests discuss the most abundant lifeform on Earth: the viruses that 'eat' bacteria. Early in the 20th century, scientists noticed that something in their Petri dishes was making bacteria disappear and they called these bacteriophages, things that eat bacteria. From studying these phages, it soon became clear that they offered countless real or potential benefits for understanding our world, from the tracking of diseases to helping unlock the secrets of DNA to treatments for long term bacterial infections. With further research, they could be an answer to the growing problem of antibiotic resistance.

With

Martha Clokie Director for the Centre for Phage Research and Professor of Microbiology at the University of Leicester

James Ebdon Professor of Environmental Microbiology at the University of Brighton

And

Claas Kirchhelle Historian and Chargé de Recherche at the French National Institute of Health and Medical Research’s CERMES3 Unit in Paris.

Producer: Simon Tillotson

In Our Time is a BBC Studios Audio Production

Reading list:

James Ebdon, ‘Tackling sources of contamination in water: The age of phage’ (Microbiologist, Society for Applied Microbiology, Vol 20.1, 2022)

Thomas Häusler, Viruses vs. Superbugs: A Solution to the Antibiotics Crisis? (Palgrave Macmillan, 2006)

Tom Ireland, The Good Virus: The Untold Story of Phages: The Mysterious Microbes that Rule Our World, Shape Our Health and Can Save Our Future (Hodder Press, 2024)

Claas Kirchhelle and Charlotte Kirchhelle, ‘Northern Normal–Laboratory Networks, Microbial Culture Collections, and Taxonomies of Power (1939-2000)’ (SocArXiv Papers, 2024)

Dmitriy Myelnikov, ‘An alternative cure: the adoption and survival of bacteriophage therapy in the USSR, 1922–1955’ (Journal of the History of Medicine and Allied Sciences 73, no. 4, 2018)

Forest Rohwer, Merry Youle, Heather Maughan and Nao Hisakawa, Life in our Phage World: A Centennial Field Guide to Earth’s most Diverse Inhabitants (Wholon, 2014)

Steffanie Strathdee and Thomas Patterson (2019) The Perfect Predator: A Scientist’s Race to Save Her Husband from a Deadly Superbug: A Memoir (Hachette Books, 2020)

William C. Summers, Félix d`Herelle and the Origins of Molecular Biology (Yale University Press, 1999)

William C. Summers, The American Phage Group: Founders of Molecular Biology (University Press, 2023)


Melvyn Bragg and a panel of academic experts gather each week to explore the vast history of scientific thought on In Our Time: Science. This BBC Radio 4 podcast delves far beyond simple explanations, instead tracing the long and often winding paths of discovery that shaped our understanding of the world. Each episode focuses on a single idea, from the concept of zero to the theory of plate tectonics, unpacking its origins, the controversies it sparked, and the key figures who championed or challenged it. You’ll hear lively, in-depth conversations that place science firmly within its human and historical context, revealing how principles we take for granted today were hard-won through centuries of debate, accident, and insight. The discussions are rigorous and accessible, designed for the curious mind eager to appreciate not just what we know, but how we came to know it. By treating science as a deeply historical endeavour, this series offers a richer appreciation of the discipline itself. Tune in for a thoughtful and engaging journey through the experiments, the arguments, and the brilliant flashes of imagination that have defined our quest for knowledge.
Author: Language: English Episodes: 100

In Our Time: Science
Podcast Episodes
Dorothy Hodgkin [not-audio_url] [/not-audio_url]

Duration: 52:22
Melvyn Bragg and guests discuss the work and ideas of Dorothy Crowfoot Hodgkin (1910-1994), awarded the Nobel Prize in Chemistry in 1964 for revealing the structures of vitamin B12 and penicillin and who later determined…
Kinetic Theory [not-audio_url] [/not-audio_url]

Duration: 51:38
Melvyn Bragg and guests discuss how scientists sought to understand the properties of gases and the relationship between pressure and volume, and what that search unlocked. Newton theorised that there were static particl…
The Evolution of Teeth [not-audio_url] [/not-audio_url]

Duration: 49:15
Melvyn Bragg and guests discuss theories about the origins of teeth in vertebrates, and what we can learn from sharks in particular and their ancestors. Great white sharks can produce up to 100,000 teeth in their lifetim…
Pheromones [not-audio_url] [/not-audio_url]

Duration: 49:09
Melvyn Bragg and guests discuss how members of the same species send each other invisible chemical signals to influence the way they behave. Pheromones are used by species across the animal kingdom in a variety of ways,…
Aristotle's Biology [not-audio_url] [/not-audio_url]

Duration: 50:10
Melvyn Bragg and guests discuss the remarkable achievement of Aristotle (384-322BC) in the realm of biological investigation, for which he has been called the originator of the scientific study of life. Known mainly as a…
Emmy Noether [not-audio_url] [/not-audio_url]

Duration: 48:20
Melvyn Bragg and guests discuss the ideas and life of one of the greatest mathematicians of the 20th century, Emmy Noether. Noether’s Theorem is regarded as one of the most important mathematical theorems, influencing th…
Venus [not-audio_url] [/not-audio_url]

Duration: 50:25
Melvyn Bragg and guests discuss the planet Venus which is both the morning star and the evening star, rotates backwards at walking speed and has a day which is longer than its year. It has long been called Earth’s twin,…
Free Radicals [not-audio_url] [/not-audio_url]

Duration: 51:03
Melvyn Bragg and guests discuss the properties of atoms or molecules with a single unpaired electron, which tend to be more reactive, keen to seize an electron to make it a pair. In the atmosphere, they are linked to rea…
Automata [not-audio_url] [/not-audio_url]

Duration: 52:23
Melvyn Bragg and guests discuss the history of real and imagined machines that appear to be living, and the questions they raise about life and creation. Even in myth they are made by humans, not born. The classical Gree…
Echolocation [not-audio_url] [/not-audio_url]

Duration: 51:02
Melvyn Bragg and guests discuss how some bats, dolphins and other animals emit sounds at high frequencies to explore their environments, rather than sight. This was such an unlikely possibility, to natural historians fro…