Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's with Charles Piller

In this episode of Inquiring Minds, host Indre Viskontas speaks with investigative journalist Charles Piller about his explosive new book, Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's. Piller unearths the troubling reality behind decades of Alzheimer's research, exposing how fraudulent data, unchecked ambition, and institutional failures have shaped the field—and wasted billions of dollars—while millions of patients and families await real solutions. Piller shares: How a single falsified study published in Nature helped cement the amyloid hypothesis as the dominant theory of Alzheimer’s, despite mounting evidence against it. The role of NIH funding incentives in steering researchers toward confirming flawed findings instead of exploring alternative approaches. The rise of scientific sleuths and whistleblowers like Matthew Schrag, who uncovered image manipulation in key Alzheimer’s studies. The institutional failures of major scientific journals, regulatory agencies, and funding bodies that allowed bad science to shape drug development for decades. Why Alzheimer’s patients and their families are still waiting for effective treatments, and what promising new directions could finally lead to breakthroughs. Despite the troubling revelations, Piller also highlights reasons for optimism, including emerging research into alternative causes of Alzheimer’s, such as viral infections and neuroinflammation, and promising clinical trials involving GLP-1 inhibitors. Listen in for a gripping and eye-opening discussion about how scientific fraud derailed progress in Alzheimer’s research—and how we can chart a new path forward. Doctored is available now at booksellers everywhere.