November 11, 2025: Precision, Place, and the Future of Cardiovascular Prediction | JACC This Week

November 11, 2025: Precision, Place, and the Future of Cardiovascular Prediction | JACC This Week

Author: American College of Cardiology November 3, 2025 Duration: 19:33

In this week's JACC podcast, Editor-in-Chief Dr. Harlan Krumholz explores how context, precision, and physiology converge to shape modern cardiovascular care. He opens with an editorial on "The Geography Gap," challenging the one-size-fits-all approach to cardiovascular risk models that ignore geographic variation in disease outcomes. Other featured studies in this issue include trials (OCEAN Mitral, PULSE), optimizing outcomes after transcatheter mitral repair, plus uncovering genetic links between placental malperfusion and congenital heart disease, evaluating CT angiography follow-up after left main PCI, and refining emergency triage with high-sensitivity troponin testing. Dr. Krumholz also speaks to editorials in this issue providing insight on the accompanying JACC articles, and a HeartBeat submission, with a reflection on balance and compassion in pediatric cardiology. Finally, he touches on our other JACC journal content, including new findings on blood groups and COVID-19 cardiovascular outcomes, and the first JACC: Basic to Translational Science Editor's page from the new editor-in-chief, Matthias Nahrendorf, MD, PhD, on the evolving landscape of translational science. This week in JACC highlights cardiology's movement toward more localized, integrated, and human-centered precision medicine.


Every week, the editors of one of the world's leading cardiology journals sit down for a conversation that goes beyond the printed page. JACC This Week, from the American College of Cardiology, brings together Editor-in-Chief Dr. Harlan Krumholz and Senior Consulting Editor Dr. Carolyn S.P. Lam. Their discussions provide essential context for the complex research published in the Journal of the American College of Cardiology, translating high-level science into meaningful insights. You’ll hear them dissect new studies, debate emerging trends, and explore the real-world implications of the latest findings in cardiovascular medicine. This isn't just a summary of the issues; it's a dialogue about how evidence is shaping modern heart care, from prevention to advanced intervention. The podcast serves as a direct line to the experts who are curating the science that defines global standards. Each episode feels like joining an informed, behind-the-scenes editorial meeting, where the nuances of patient care and clinical practice are thoughtfully examined. For anyone invested in cardiology-whether a practicing clinician, a researcher, or a dedicated student-this regular audio companion offers clarity and a deeper understanding of the forces driving the field forward. It’s where the published data meets practical conversation, all through the accessible format of a weekly podcast.
Author: Language: English Episodes: 50

JACC This Week
Podcast Episodes
JACC Editor's Page: June 30, 2025 | JACC [not-audio_url] [/not-audio_url]

Duration: 4:30
Cardiac electrophysiology is rapidly evolving, blending procedural expertise with innovations in pharmacotherapy, device design, and lifestyle medicine. This week's Editor's Page spotlights key studies from JACC that cha…
JACC Editor's Page: July 7. 2025 | JACC [not-audio_url] [/not-audio_url]

Duration: 5:59
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IHCA Incidence Rates | JACC Deep Dive [not-audio_url] [/not-audio_url]

Duration: 6:28
In this JACC Deep Dive, Harlan M. Krumholz, MD, SM, FACC, discusses a new study in the July 8 issue of JACC, authored by Saket Girotra MD, SM, et al. In the study, which links national registry and Medicare data, the aut…
Plaque Vulnerability and Risk Factors | JACC Deep Dive [not-audio_url] [/not-audio_url]

Duration: 5:38
In this JACC Deep Dive, Harlan M. Krumholz, MD, SM, FACC reviews a study by Covani, et al that uses OCT imaging in over 1,500 ACS patients to show how increasing cardiovascular risk factor burden—like smoking, diabetes,…
Validation of AHA PREVENT in Healthcare Populations | JACC Deep Dive [not-audio_url] [/not-audio_url]

Duration: 6:29
Validation of AHA PREVENT in healthcare populations| JACC Deep Dive In this JACC Deep Dive, JACC Editor in Chief Harlan M. Krumholz, MD, SM, explores a study led by Dr. Pradeep Natarajan that evaluates how well the new A…
ACURATE neo2 Under-Expansion | JACC Deep Dive [not-audio_url] [/not-audio_url]

Duration: 15:11
JACC's July 29 issue explores why the ACURATE neo2 valve failed in its IDE trial, with a post-hoc analysis pointing to under-expansion in heavily calcified anatomies as a potential culprit. Though the valve is off the ma…