November 25, 2025: Clonal Hematopoiesis, Alcohol and Blood Pressure, Long-Term Risk, and Emerging Biomarkers | JACC This Week

November 25, 2025: Clonal Hematopoiesis, Alcohol and Blood Pressure, Long-Term Risk, and Emerging Biomarkers | JACC This Week

Author: American College of Cardiology November 17, 2025 Duration: 16:18

JACC's November 25, 2025 issue kicks off Thanksgiving week with JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, reflecting on his editor's page and the day he became a doctor (0:12).  For original research articles, he discusses a study on colchicine & clonal hematopoiesis, an exploratory study of the LoDoCo2 trial (1:10), and a paired editorial comment with more perspectives and a reminder of the upcoming COLCOT trial (4:33). Next, a study on Lp(a) and IL-6 (4:54) and an editorial (6:12), 30-year CVD risk percentiles based on the PREVENT equations (6:30), and an accompanying editorial from JACC Deputy Editor Erica Spatz, MD, on next-generation strategies to encourage healthier behaviors (7:35).  Other studies and editorials include a fascinating look at alcohol and blood pressure (8:04) and reinforcing the WHO public health guidance (10:05); remnant cholesterol in young adults (10:38) and implications for cholesterol guidelines (12:36). We also include four brief reports on RSV vaccine (13:11), long Covid (13:43), Lp(a) levels (14:06), the predictive power of polygenic risk scores (14:58), a viewpoint on US veterans (15:36), and our regular Amara Yad image (15:53), which we're delighted to be able to continue to promote with JACC: Clinical Electrophysiology Editor-in-Chief Kalyanam Shivkumar, MD.

 


Every week, the editors of one of the world's leading cardiology journals sit down for a conversation that goes beyond the printed page. JACC This Week, from the American College of Cardiology, brings together Editor-in-Chief Dr. Harlan Krumholz and Senior Consulting Editor Dr. Carolyn S.P. Lam. Their discussions provide essential context for the complex research published in the Journal of the American College of Cardiology, translating high-level science into meaningful insights. You’ll hear them dissect new studies, debate emerging trends, and explore the real-world implications of the latest findings in cardiovascular medicine. This isn't just a summary of the issues; it's a dialogue about how evidence is shaping modern heart care, from prevention to advanced intervention. The podcast serves as a direct line to the experts who are curating the science that defines global standards. Each episode feels like joining an informed, behind-the-scenes editorial meeting, where the nuances of patient care and clinical practice are thoughtfully examined. For anyone invested in cardiology-whether a practicing clinician, a researcher, or a dedicated student-this regular audio companion offers clarity and a deeper understanding of the forces driving the field forward. It’s where the published data meets practical conversation, all through the accessible format of a weekly podcast.
Author: Language: English Episodes: 50

JACC This Week
Podcast Episodes
Reframing Cardiovascular Care | JACC This Week [not-audio_url] [/not-audio_url]

Duration: 13:24
In this episode, Dr. Harlan Krumholz introduces the September 16, 2025 issue of JACC, which features studies that challenge conventional clinical thinking, including a detailed ECMO physiology study showing that higher E…
Device Safety, DAPT Strategy & Structural Innovation | JACC This Week [not-audio_url] [/not-audio_url]

Duration: 18:45
In this episode of JACC This Week, Editor-in-Chief Dr. Harlan Krumholz explores device safety, abbreviated DAPT, drug-coated balloons, and a novel surgical polymer valve. Plus: expert insights on cardiovascular innovatio…
Epidemiology and Outcomes in HFimpEF | JACC Deep Dive [not-audio_url] [/not-audio_url]

Duration: 8:31
In this JACC Deep Dive, Editor-in-Chief Harlan M. Krumholz, MD, SM, discusses a large real-world study by Min et al. examining heart failure with improved ejection fraction (HFimpEF) in over 24,000 patients. The study fo…