Bleeding Risk with Apixaban vs Rivaroxaban for Acute VTE (COBRRA), Left Atrial Appendage Closure vs Medical Therapy for Atrial Fibrillation (CLOSURE-AF)

Bleeding Risk with Apixaban vs Rivaroxaban for Acute VTE (COBRRA), Left Atrial Appendage Closure vs Medical Therapy for Atrial Fibrillation (CLOSURE-AF)

Author: Stephen Jenkins, MD, Austin Rupp, MD March 28, 2026 Duration: 35:37
We are back with a landmark trial -- COBRRA was finally published! Apixaban wins again, but is rivaroxaban done for good?? Also, is left atrial appendage occlusion safer than oral anticoagulation in patients with a high risk of stroke and a high risk of bleeding? Check it out! Apixaban vs Rivaroxaban for Acute VTE (COBRRA) Left Atrial Appendage Closure vs Medical Management (CLOSURE-AF) Music from Uppbeat (free for Creators!): https://uppbeat.io/t/soundroll/dope License code: NP8HLP5W...

Keeping up with the flood of new medical research can feel like a full-time job on top of your actual one. That’s where Last Week in Medicine comes in. Hosted by practicing physicians Stephen Jenkins and Austin Rupp, this weekly audio digest is built for clinicians, students, and anyone deeply interested in evidence-based medicine who needs a practical filter for the noise. Instead of spending hours scrolling through tables of contents, you get a curated review of significant findings from top-tier journals like The New England Journal of Medicine, The Lancet, and the JAMA Network, all discussed in a conversational, accessible tone. Each episode breaks down the methodology and clinical implications of recent studies, offering context you won’t find in an abstract. It’s designed to fit into a commute or a workout, transforming dense literature into actionable insight. By tuning in, you’re not just getting updates; you’re hearing two doctors analyze what these advances mean for real-world practice, from hospital medicine to outpatient care. This podcast serves as your ongoing medical education, covering a broad spectrum that includes mental health, fitness, and alternative approaches, all through a rigorous, internal medicine lens. Let Drs. Jenkins and Rupp do the reading, so you can spend your time applying what matters.
Author: Language: en-us Episodes: 67

Last Week in Medicine
Podcast Episodes
Weekly Semaglutide for Weight Loss (STEP 1, 2 and 3 Trials), 4PEPS Rule for Pulmonary Embolism, Nafcillin vs Cefazolin for Epidural Abscess, Ferritin/Procalcitonin Ratio for COVID19, Intermediate Thromboprophylaxis for COVID19 [not-audio_url] [/not-audio_url]

Duration: 50:49
Today we are doing double duty: podcasting and parenting. Fortunately our babies were well-behaved. We talk about three trials for semaglutide and weight loss and a new 4 level pre-test probability rule for diagnosing PE…
Thrombosis and COVID-19 [not-audio_url] [/not-audio_url]

Duration: 17:09
Today I do a quick review of the COVID-19 thrombosis literature from the last year to try to answer some of the following questions: Why does COVID-19 cause thrombosis? How many patients with COVID-19 develop thrombotic…