Gadolinium in CKD Stage 4 and 5, Metoprolol and COPD Exacerbations, Vitamin D in Critically Ill Patients, Politics and Mood in Young Physicians

Gadolinium in CKD Stage 4 and 5, Metoprolol and COPD Exacerbations, Vitamin D in Critically Ill Patients, Politics and Mood in Young Physicians

Author: Stephen Jenkins, MD, Austin Rupp, MD December 17, 2019 Duration: 25:14
Dr. Rupp is back! Today we talk about whether it's safe to give group 2 gadolinium based contrast agents to patients with CKD stage 4 and 5 and whether metoprolol can be used to prevent COPD exacerbations. We also shine some more sunlight on the sunshine vitamin's inability to change any meaningful outcomes, and discuss some interesting data from the Intern Health Study. Risk of Nephrogenic Systemic Fibrosis in Patients with Stage 4 or 5 CKD Receiving Group II Gadolinium Based Contras...

Keeping up with the flood of new medical research can feel like a full-time job on top of your actual one. That’s where Last Week in Medicine comes in. Hosted by practicing physicians Stephen Jenkins and Austin Rupp, this weekly audio digest is built for clinicians, students, and anyone deeply interested in evidence-based medicine who needs a practical filter for the noise. Instead of spending hours scrolling through tables of contents, you get a curated review of significant findings from top-tier journals like The New England Journal of Medicine, The Lancet, and the JAMA Network, all discussed in a conversational, accessible tone. Each episode breaks down the methodology and clinical implications of recent studies, offering context you won’t find in an abstract. It’s designed to fit into a commute or a workout, transforming dense literature into actionable insight. By tuning in, you’re not just getting updates; you’re hearing two doctors analyze what these advances mean for real-world practice, from hospital medicine to outpatient care. This podcast serves as your ongoing medical education, covering a broad spectrum that includes mental health, fitness, and alternative approaches, all through a rigorous, internal medicine lens. Let Drs. Jenkins and Rupp do the reading, so you can spend your time applying what matters.
Author: Language: en-us Episodes: 67

Last Week in Medicine
Podcast Episodes
2026 ACC/AHA Guidelines for Acute Pulmonary Embolism [not-audio_url] [/not-audio_url]

Duration: 48:28
The ACC/AHA published new guidelines for managing acute PE on February 19, 2026. Today I'm joined by Dr. Scott Woller, MD, MACP, FCCP, who was co-chair of the American College of Chest Physicians Clinical Practice Guidel…
Hematopoietic Stem Cell Gene Therapy for Cystinosis [not-audio_url] [/not-audio_url]

Duration: 41:45
In this episode I'm joined by senior author Dr. Stephanie Cherqui to talk about her recent publication in the New England Journal of Medicine on gene therapy for cystinosis. This is a very personal episode for me, becaus…
Extended Apixaban for Provoked VTE (HI-PRO), Coffee and Atrial Fibrillation (DECAF), Age-Adjusted D-dimer for DVT, Beta Blockers after MI with Normal EF, Fish Oil for Dialysis (PISCES), Conservative Dialysis for AKI (LIBERATE-D) [not-audio_url] [/not-audio_url]

Duration: 1:11:27
In this episode, Dr. Austin Rupp and I try to answer the following questions: Should patients with provoked VTE be offered long term anticoagulation if they have persistent risk factors, like obesity? Does coffee make at…
Hydrocortisone for Severe Pneumonia (REMAP-CAP), Intensive BP Control in Diabetes (BPROAD), Aldosterone Synthase Inhibitors for Hypertension (ADVANCE-HTN), Reduced-dose Apixaban for Cancer Associated Thrombosis (API-CAT) [not-audio_url] [/not-audio_url]

Duration: 56:43
What do you do when most trials suggest benefit for an intervention, but then a new trial suggests harm? We thought steroids in pneumonia was a settled question, but REMAP-CAP had other plans! We also review a new RCT fo…
Half Dose DOAC for Long Term VTE Prevention, Biomarker Guided Antibiotics for Sepsis, GPT-4 Assistance for Physicians, Optimal Vasopressin Initiation for Shock, DOAC vs No AC for A fib After Intracerebral Hemorrhage, HFNC vs NIV for Respiratory Failure [not-audio_url] [/not-audio_url]

Duration: 1:32:52
For this episode we are joined by EBM guru, Dr. Brian Locke, who deftly breaks down all of our statistics questions. Is half dose DOAC as good as full dose DOAC for preventing VTE, and does it reduce bleeding risk? Can p…
Anticoagulation in AF with Cirrhosis, Trends in Anticoagulation for Acute PE, Beta Blockers for Acute MI with Normal EF, Finerenone for HFpEF, Continuous vs Intermittent Infusion for Antibiotics, Cefepime vs Piperacillin-Tazobactam for Sepsis [not-audio_url] [/not-audio_url]

Duration: 1:05:23
It's been a long time, but we are back! Apologies on the audio quality from Dr. Jenkins. Apparently he was recording from inside a cardboard box. Today we talk about important, practice changing studies in internal medic…