Hydrocortisone for Severe Pneumonia (REMAP-CAP), Intensive BP Control in Diabetes (BPROAD), Aldosterone Synthase Inhibitors for Hypertension (ADVANCE-HTN), Reduced-dose Apixaban for Cancer Associated Thrombosis (API-CAT)

Hydrocortisone for Severe Pneumonia (REMAP-CAP), Intensive BP Control in Diabetes (BPROAD), Aldosterone Synthase Inhibitors for Hypertension (ADVANCE-HTN), Reduced-dose Apixaban for Cancer Associated Thrombosis (API-CAT)

Author: Stephen Jenkins, MD, Austin Rupp, MD April 25, 2025 Duration: 56:43
What do you do when most trials suggest benefit for an intervention, but then a new trial suggests harm? We thought steroids in pneumonia was a settled question, but REMAP-CAP had other plans! We also review a new RCT for BP targets in patients with hypertension and diabetes, a new aldosterone synthase inhibitor for hypertension, and reduced dose apixaban for cancer-associated thrombosis. Hydrocortisone for Severe CAP (REMAP-CAP) Predicting Benefit of Corticosteroids in Pneumonia Intens...

Keeping up with the flood of new medical research can feel like a full-time job on top of your actual one. That’s where Last Week in Medicine comes in. Hosted by practicing physicians Stephen Jenkins and Austin Rupp, this weekly audio digest is built for clinicians, students, and anyone deeply interested in evidence-based medicine who needs a practical filter for the noise. Instead of spending hours scrolling through tables of contents, you get a curated review of significant findings from top-tier journals like The New England Journal of Medicine, The Lancet, and the JAMA Network, all discussed in a conversational, accessible tone. Each episode breaks down the methodology and clinical implications of recent studies, offering context you won’t find in an abstract. It’s designed to fit into a commute or a workout, transforming dense literature into actionable insight. By tuning in, you’re not just getting updates; you’re hearing two doctors analyze what these advances mean for real-world practice, from hospital medicine to outpatient care. This podcast serves as your ongoing medical education, covering a broad spectrum that includes mental health, fitness, and alternative approaches, all through a rigorous, internal medicine lens. Let Drs. Jenkins and Rupp do the reading, so you can spend your time applying what matters.
Author: Language: en-us Episodes: 67

Last Week in Medicine
Podcast Episodes
Inappropriate Testing and Treating of Asymptomatic Bacteriuria, Baricitinib Plus Remdesivir for COVID-19 (ACTT-2), COVID-19 Vaccine, Noninvasive Respiratory Protocol for COVID-19, Iron Supplementation in Acute Heart Failure [not-audio_url] [/not-audio_url]

Duration: 47:18
Today we have special guest Dr. Valerie Vaughn to talk about her new paper in Open Forum Infectious Diseases about inappropriate treatment and testing for asymptomatic bacteriuria. Then we talk about the new ACTT-2 trial…
Caring for COVID-19 Patients in the Navajo Nation [not-audio_url] [/not-audio_url]

Duration: 34:43
Today we are joined by a special guest, Dr. Lawanda Jim, chief of internal medicine at Northern Navajo Medical Center, to talk about what it's been like taking care of patients during the pandemic in Shiprock, NM. Check…
Dexamethasone Reduces Mortality in COVID-19: The RECOVERY Trial [not-audio_url] [/not-audio_url]

Duration: 30:29
Today we're back with a spirited discussion of a pre-print publication for the dexamethasone arm of the RECOVERY trial. Should hospitalized COVID19 patients receive dexamethasone? Take a listen and decide for yourself. D…