The Dark Side of Human Optimisation: Nicotine, Peptides, NAD+ & the Enhanced Games | Longevity Doctor Explains

The Dark Side of Human Optimisation: Nicotine, Peptides, NAD+ & the Enhanced Games | Longevity Doctor Explains

Author: Sarah Ann Macklin August 26, 2026 Duration: 1:35:57

This week I'm joined by Dr Jack Kreindler, physician, healthtech entrepreneur and founder of WellFounded Health and the Centre for Health and Human Performance, and someone who has spent 26 years asking one of the most important questions in medicine, what does it mean to not just fix disease, but to truly enhance human life?

We explore longevity, prevention, performance and what the most advanced medicine in the world is learning about how to live well for longer.

Dr Jack Kreindler qualified in medicine and physiology from University College London and spent a decade as an emergency physician before founding the Centre for Health and Human Performance in Harley Street in 2007. He is an honorary clinical research fellow at Imperial College London, founder and CEO of WellFounded Health and a leading voice on healthy longevity, human performance and the future of medicine. He has worked with elite athletes, extreme environment explorers and high performance executives across the world.

What we explore together:

  • Why medicine is shifting from fixing disease to enhancing physiology and what that means for you

  • What burning the candle at three ends is actually doing to your brain and body

  • Why cadence is king and how everything in nature and biology moves in waves

  • What the most advanced health testing actually looks like and what it tells us

  • The truth about longevity supplements, peptides and biohacking and who they actually work for

  • Why your history is still the most powerful diagnostic tool ever invented

  • What it really means to enhance a human life rather than just extend it

Love, Sarah Ann 💛

My book 'Healthy Shouldn't Be This Hard': https://www.amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5

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Chapters

00:00 Introduction

02:59 How Jack's view of medicine changed over 26 years

05:58 Burning the candle at three ends and what it costs you

09:04 Why cadence is king in biology and life

12:00 What a prevention first approach to health looks like

18:00 Your history from one cell to 38 trillion

21:02 What advanced health testing actually reveals

30:00 Hormones, menopause and andropause

33:02 Cardiovascular risk and how to assess it properly

36:00 Brain health, dementia risk and what you can do now

39:07 The gut microbiome and its role in everything

42:00 Extreme environments and what they teach us about health

45:08 Elite sport science applied to everyday health

48:00 The longevity space and what the evidence actually shows

51:07 Peptides, supplements and biohacking

54:06 What works, what doesn't and how to know the difference

57:07 AI and the future of personalised medicine

66:04 The bell shaped curve and why nothing works for everyone

69:08 What enhancing a human life really means

72:00 Not dying dull and what Jack has learned

75:02 Final thoughts on living well and being well



There's a lot of noise out there about what it means to be healthy, and Live Well Be Well with Sarah Ann Macklin cuts straight through it. Sarah Ann brings a grounded perspective shaped by both personal experience and formal study, moving beyond quick fixes to explore what sustainable wellness actually looks like. Each conversation in this podcast feels like a thoughtful exploration rather than a lecture, tackling the interconnected areas of holistic health, practical nutrition, and realistic lifestyle shifts. You'll hear from a range of insightful guests alongside Sarah Ann's own reflections, all aimed at making sense of the information overload. The tone is refreshingly human-this isn't about perfection, but about finding a smarter, more integrated approach to everyday living. Tuning into this podcast feels like gaining a knowledgeable, empathetic friend who believes that feeling well shouldn't feel like a constant struggle. It’s a space for anyone wanting to move past the confusion and cultivate a genuine sense of vitality that fits into a real, busy life.
Author: Language: English Episodes: 50

Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition
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