A New Paradigm for Severe COVID

A New Paradigm for Severe COVID

Author: Chris Masterjohn, PhD May 25, 2022 Duration: 1:10:46

This new model I developed explains how the depletion of arginine and tryptophan and the sequestration of cysteine leads to T cell suppression in severe COVID and may reflect the rapid onset of a somewhat cancer-reminiscent state where vitamins A and D and other myeloid differentiation factors run out.

The written version with references and links to research is available here:

https://chrismasterjohnphd.substack.com/p/a-new-paradigm-for-severe-covid

If you find this valuable, please like, share, and comment on the Substack article to help boost it within the Substack algorithm and get more people to read it.

Vitamins A and D should be properly balanced with each other, and with vitamins E and K. My COVID-specific recommendations for this balance are in the COVID Guide, and recommendations for balancing them in various different contexts are included in the Vitamins and Minerals 101 Cliff Notes, both of which are freely available to paid Substack subscribers.

These also contain general (Cliff Notes) or COVID-specific (COVID Guide) information for managing all the other nutrients mentioned. I will be updating the COVID guide next time to include tryptophan and N-acetylcysteine whenever arginine is used, but other than that this new paradigm does not alter the protocol. It does, however, move much more emphasis to A and D, and bring A onto much more equal footing with D.

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Paid Subscriptions, Coming Guides, the Book

My current plan is to wrap up a vaccine side effect protocol and my general work on the vaccines into a COVID Vaccine Guide that will be free to those who have pre-ordered my book, Masterpass members, and paid Substack subscribers. I will then do one final update to the COVID guide, also free to everyone I just mentioned. Paid Substack subscribers and Masterpass members will also have access to all paid-only Substack posts, which are the posts that feed into the creation of the vaccine side effect protocol. Most of these will be available for 48 hours to everyone. You can become a paid Substack subscriber here, which earns you 50% off the fee on Masterpass membership if you choose to join. The book can be pre-ordered here. As soon as these two guides are finished I will return full-time to finishing the book and will send everyone who pre-ordered an ETA as soon as I am ready.

Take a Look at the Store

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Recommendations for peripheral neuropathy | Masterjohn Q&A Files #24 [not-audio_url] [/not-audio_url]

Duration: 1:31
Question: "Any recommendations for peripheral neuropathy? Testing vitamin B, lion's mane?" First of all, there is no such thing as vitamin B. I'm not trying to be a nitpick, but there's literally almost a dozen B vitamin…
How to improve LDL receptor activity. | Masterjohn Q&A Files #23 [not-audio_url] [/not-audio_url]

Duration: 1:40
Question: "If cholesterol, LDL-P, and oxidized LDL are high, the sterol panel is normal, and TGs are great, would you suspect clearance of the particles driven by LDL receptor in the liver is the issue, and what would yo…
How to lower your calcium score | Masterjohn Q&A Files #21 [not-audio_url] [/not-audio_url]

Duration: 3:55
Question: "Calcium score, is there a way to treat one's calcium score and get it to zero?" ⇒ No, you don't treat the calcium score. You take the calcium score as indicative of what's going on in atherosclerosis, and you…
How to address edema. | Masterjohn Q&A Files #19 [not-audio_url] [/not-audio_url]

Duration: 3:49
Question: How do I address edema? Edema is basically going to be caused by excess salt retention in the body. The reason is that with the exception of very extreme scenarios, your body is going to tightly regulate the so…