A New Paradigm for Severe COVID

A New Paradigm for Severe COVID

Author: Chris Masterjohn, PhD May 25, 2022 Duration: 1:10:46

This new model I developed explains how the depletion of arginine and tryptophan and the sequestration of cysteine leads to T cell suppression in severe COVID and may reflect the rapid onset of a somewhat cancer-reminiscent state where vitamins A and D and other myeloid differentiation factors run out.

The written version with references and links to research is available here:

https://chrismasterjohnphd.substack.com/p/a-new-paradigm-for-severe-covid

If you find this valuable, please like, share, and comment on the Substack article to help boost it within the Substack algorithm and get more people to read it.

Vitamins A and D should be properly balanced with each other, and with vitamins E and K. My COVID-specific recommendations for this balance are in the COVID Guide, and recommendations for balancing them in various different contexts are included in the Vitamins and Minerals 101 Cliff Notes, both of which are freely available to paid Substack subscribers.

These also contain general (Cliff Notes) or COVID-specific (COVID Guide) information for managing all the other nutrients mentioned. I will be updating the COVID guide next time to include tryptophan and N-acetylcysteine whenever arginine is used, but other than that this new paradigm does not alter the protocol. It does, however, move much more emphasis to A and D, and bring A onto much more equal footing with D.

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Paid Subscriptions, Coming Guides, the Book

My current plan is to wrap up a vaccine side effect protocol and my general work on the vaccines into a COVID Vaccine Guide that will be free to those who have pre-ordered my book, Masterpass members, and paid Substack subscribers. I will then do one final update to the COVID guide, also free to everyone I just mentioned. Paid Substack subscribers and Masterpass members will also have access to all paid-only Substack posts, which are the posts that feed into the creation of the vaccine side effect protocol. Most of these will be available for 48 hours to everyone. You can become a paid Substack subscriber here, which earns you 50% off the fee on Masterpass membership if you choose to join. The book can be pre-ordered here. As soon as these two guides are finished I will return full-time to finishing the book and will send everyone who pre-ordered an ETA as soon as I am ready.

Take a Look at the Store

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Staying Immune Through the Winter [not-audio_url] [/not-audio_url]

Duration: 0:53
Get my new 7-page quick guide on how to not get sick for free when you sign up to my Substack: https://chrismasterjohnphd.substack.com/p/staying-immune-through-the-winter Chris Masterjohn, PhD, is the Founder and Scienti…
How to Increase or Decrease SHBG? | Masterjohn Q&A Files #302 [not-audio_url] [/not-audio_url]

Duration: 14:58
Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance,…
COVID Vaccine Side Effects: What Causes Them? [not-audio_url] [/not-audio_url]

Duration: 1:51:03
I am done with my work on COVID vaccines, at least until I finish my Vitamins and Minerals 101 Book, so I am now making my scientific review on the likely causes of COVID vaccine side effects public. This is an excerpt o…
Protein and Longevity | Masterjohn Q&A Files #301 [not-audio_url] [/not-audio_url]

Duration: 33:03
Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of prote…
Chips! The Only Ones I'll Endorse [not-audio_url] [/not-audio_url]

Duration: 5:08
My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new tortilla chip that launches today! MASA chips are made from organic corn…
The Ancestral Health Debate [not-audio_url] [/not-audio_url]

Duration: 2:16:15
Nick Hiebert and I debate the value of ancestral health as a framework for approaching health in the modern era. For my summary of and reflections on the debate, as well as time stamps, relevant links, and a transcript,…