Depression Starts In Your Mitochondria

Depression Starts In Your Mitochondria

Author: Chris Masterjohn, PhD December 16, 2025 Duration: 6:47

You could be one metabolic bottleneck away from feeling amazing.

Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease.

Find it at mito.me 

This is not medical advice and is for educational purposes only.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Explaining the "Hospitalization Paradox" [not-audio_url] [/not-audio_url]

Duration: 1:17:50
https://chrismasterjohnphd.com/paradox Please subscribe to my Substack at https://chrismasterjohnphd.substack.com Subscription is completely free but if you take the option to pay $5 a month or $30 per year, you will get…
I'm About to Get Deplatformed [not-audio_url] [/not-audio_url]

Duration: 20:12
I'm recording from "Youtube Jail," where I'll be until Monday morning. Two more strikes and I'm out. Please help our community stay connected by joining my email list at https://chrismasterjohnphd.com/uncensored Chris Ma…
The Hospitals Are Not Full of COVID Patients [not-audio_url] [/not-audio_url]

Duration: 16:53
The pandemic that no one dare speak of: 79% of people hospitalized for COVID-like illness test negative for COVID. The vaccines protect against testing positive among those hospitalized, but not against winding up in the…
Strategizing Against Vaccine Mandates with Angela McArdle [not-audio_url] [/not-audio_url]

Duration: 1:26:19
In this episode, Chris Masterjohn interviews Angela McArdle on strategies to defeat the mandates. McArdle is the current chair of the Los Angeles Libertarian Party and is spearheading an effort to amend the New York City…
Angela McArdle [not-audio_url] [/not-audio_url]

Duration: 1:29:04
Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.
Dmitry Kats, PhD: From Niatonin to Niacur [not-audio_url] [/not-audio_url]

Duration: 3:43:11
In this episode, I have Dr. Dmitry Kats, MPH, PhD. He has a PhD in epidemiology from the University of North Carolina at Chapel Hill. Many people have asked me what I think of his Niatonin protocol for COVID. And as you'…
Jessica Rose: Adverse Events Reporting and Much More [not-audio_url] [/not-audio_url]

Duration: 3:09:59
In this episode, I have a fascinating 3-hour conversation with Dr. Jessica Rose about all things related to C-word juices, ranging from interpreting the adverse event reporting system to the future of mandatory prophylac…
Patenting the Human Genome With Law Professor Jorge L. Contreras [not-audio_url] [/not-audio_url]

Duration: 1:44:21
In this episode, I interview Law Professor Jorge Contreras about the past, present, and future of biotech companies patenting the human genome. Jorge L. Contreras received his law degree from Harvard and teaches intellec…
Tess Lawrie [not-audio_url] [/not-audio_url]

Duration: 1:26:43
In this episode, I interview Tess Lawrie about Iver Mixin', public health corruption, and C-word juices. Tess is a medical doctor with expertise in research analysis and has served as an external consultant for groups at…
Stephanie Seneff [not-audio_url] [/not-audio_url]

Duration: 2:09:05
In this episode, I interview Stephanie Seneff, PhD, on her hypothesis about glyphosate, deuterium, and the C-word. Stephanie Seneff is a senior research scientist at MIT, where she has had continuous affiliation for more…