Does Erythritol Cause Heart Disease?

Does Erythritol Cause Heart Disease?

Author: Chris Masterjohn, PhD March 24, 2023 Duration: 48:37

This analysis of the recent study by the Hazen group at Cleveland Clinic published in Nature Medicine claiming erythritol contributes to cardiovascular disease shows the following:

  1. Why elevated plasma erythritol is likely to reflect thiamin deficiency and NADPH depletion from insulin resistance, inflammation, and oxidative stress

  2. Why the in vitro and mouse study blood clotting likely reflects osmotic stress with no relevance to the use of erythritol as a sweetener.

  3. Why I strongly suspect the Hazen group is hiding data, specifically the data that they obviously had a chance to collect and would have clinched their case but appears nowhere in their paper.

  4. Why even though I do not use erythritol as a sweetener, were I ever to think about doing so, the new Nature Medicine paper would play no role in my decision.

Read the analysis in written form, fully referenced, here:

https://chrismasterjohnphd.substack.com/p/erythritol-and-blood-clotting

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
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