Explaining the "Hospitalization Paradox"

Explaining the "Hospitalization Paradox"

Author: Chris Masterjohn, PhD March 4, 2022 Duration: 1:17:50

https://chrismasterjohnphd.com/paradox 

Please subscribe to my Substack at https://chrismasterjohnphd.substack.com

Subscription is completely free but if you take the option to pay $5 a month or $30 per year, you will get access to exclusive content, as well as my COVID guide for free and 50% off my Masterpass membership program.

Please like, comment on, and share the Substack version of this post. This will help spread it far and wide, as subscriber engagement drives the Substack algorithm. Engagements from paid subscribers count the most, but engagements from free subscribers come in the highest numbers and are the foundation for spreading the content.

This episode covers how a negative PCR test can serve as a marker for systemic inflammation and spike protein toxicity, creating a widely exploited statistical anomaly to make misleading claims about hospitalization.

I consider this the absolute most important topic of our decade: the core anomaly in COVID data that is exploited worldwide to claim the vaccines are protecting against hospitalization among those who get COVID, yet which is at complete odds with the CDC data showing the majority of people hospitalized for COVID-like illness are vaccinated and that the vast majority of them test negative.

"COVID-like illness" refers to the signs and symptoms of COVID, regardless of the results of a PCR test.

While the clinical fate of PCR-negative COVID-like illness is completely unclear, we cannot just ignore it.

In fact, recent evidence suggests that as much as 69% of PCR-negative COVID-like illness might be genuine COVID.

Zooming out to capture the total COVID-like illlness, the "Hospitalization Paradox" refers to the fact that the vaccines do not protect against it at all. When the vaccines have high efficacy against a negative test, all they do is make ill people test negative. In contexts where they have sub-par efficacy against a negative test — the Johnson and Johnson trial, after 3 months of being vaccinated with no booster, and in the face of increasingly vaccine-resistant variants like delta and omicron — suddenly they appear to have efficacy against hospitalization, but only among vaccinated people who test positive. The vaccinated people who test negative, by contrast, wind up in the hospital with PCR-negative COVID-like illness.

In this very extensively documented article, I argue that this can be explained by the negative test, during the waning phase, becoming a marker of vaccine-induced systemic inflammation and the persistence of spike protein in the body, contributing to acute and cumulative spike protein toxicity and possibly spike-induced autoimmunity.

Read the article here:

https://chrismasterjohnphd.com/paradox 

Please subscribe to my Substack at https://chrismasterjohnphd.substack.com

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Are You Coming to Wise Traditions? [not-audio_url] [/not-audio_url]

Duration: 4:43
Are you coming to Wise Traditions 2017? It's in Minneapolis, with some pregame events beginning on Thursday November 9th and the main conference running from Friday, November 10th through Monday, November 13th. I'm excit…
How We Make Ketones | MWM Energy Metabolism Cliff Notes #32 [not-audio_url] [/not-audio_url]

Duration: 10:11
In conditions of glucose deprivation, such as fasting or carbohydrate restriction, ketogenesis serves to reduce our needs for glucose. This reduces the need to engage in the energetically wasteful process of gluconeogene…
Cortisol and Gluconeogenesis |MWM Energy Metabolism Cliff Notes #31 [not-audio_url] [/not-audio_url]

Duration: 9:36
The last lesson covered how insulin, glucagon, and allosteric regulators from within the liver ensure that the liver only engages in gluconeogenesis when it can and when it needs to. This lesson focuses on an additional…
Regulation of Gluconeogenesis | MWM Energy Metabolism Cliff Notes #30 [not-audio_url] [/not-audio_url]

Duration: 13:39
Since gluconeogenesis is extremely expensive, it has to be tightly regulated so that it only occurs when both of two conditions are met: 1) the liver has enough energy to invest a portion into synthesizing glucose, and 2…
Gluconeogenesis |MWM Energy Metabolism Cliff Notes #29 [not-audio_url] [/not-audio_url]

Duration: 10:25
Gluconeogenesis is extremely expensive. Three steps of glycolysis are so energetically favorable that they are irreversible. Getting around them requires four gluconeogenesis-specific enzymes and the investment of a much…
The Pentose Phosphate Pathway | MWM Energy Metabolism Cliff Notes #27 [not-audio_url] [/not-audio_url]

Duration: 10:34
The pentose phosphate pathway provides a deep look into a stunning array of essential roles for glucose. In it, glucose becomes the source of NADPH, used for antioxidant defense, detoxification, recycling of nutrients li…
Are We All Evolved to Eat High Protein? | Mastering Nutrition #38 [not-audio_url] [/not-audio_url]

Duration: 1:07:15
In August of this year, 25-year-old bodybuilding mom Meegan Hefford was found unconscious in her apartment, brought to the hospital where she was declared brain-dead, and died soon after. The cause? "Too much protein bef…
Insulin Doesn't Make You Fat | MWM Energy Metabolism Cliff Notes #26 [not-audio_url] [/not-audio_url]

Duration: 12:12
Although insulin promotes storage of fat in adipose tissue, this occurs in the context of multiple layers of regulation where energy balance is the final determinant of how much fat we store. In a caloric deficit, the lo…