How to improve LDL receptor activity. | Masterjohn Q&A Files #23

How to improve LDL receptor activity. | Masterjohn Q&A Files #23

Author: Chris Masterjohn, PhD December 10, 2019 Duration: 1:40

Question: "If cholesterol, LDL-P, and oxidized LDL are high, the sterol panel is normal, and TGs are great, would you suspect clearance of the particles driven by LDL receptor in the liver is the issue, and what would you recommend to boost LDL-R?"

Yes, it sounds like you should target LDL-R. 

The big regulators of LDL-R function are thyroid hormone, and the amount of cholesterol in the liver cell, and anything that brings bile acids into the feces, and that's generally a high-fiber diet; psyllium husk would be a fiber you could add.

Thyroid hormone is the other piece of that, and that you target with higher carbohydrate intake. Higher carbohydrate intake also acts on PCSK9 to boost LDL receptor activity. 

This Q&A can also be found as part of a much longer episode, here:https://chrismasterjohnphd.com/podcast/2019/02/09/ask-anything-nutrition-feb-1-2019/ 

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
What to Do About Vitamin A Toxicity | Chris Masterjohn Lite #126 [not-audio_url] [/not-audio_url]

Duration: 6:12
If you have vitamin A toxicity, should you see a doctor? What foods should you stop eating, and are there any supplements you should start taking? Tune in for my suggestions. This episode is brought to you by Ancestral S…
Ten Steps to Healthy Sleep | Chris Masterjohn Lite #120 [not-audio_url] [/not-audio_url]

Duration: 12:16
Here are ten steps to healthy sleep! What has been most game-changing for you? Let me know in the comments! This episode is brought to you by Ancestral Supplements' Grass Fed Beef Brain. Our Native American ancestors bel…
How to Stop Waking Up to Pee | Chris Masterjohn Lite #119 [not-audio_url] [/not-audio_url]

Duration: 6:42
Don't you just hate it when you keep waking up in the middle of the night to pee? If this is your biggest sleeping problem, listen up. In this episode I cover how sleeping regular hours is one of the most important ways…