How to Recover From Fish Oil

How to Recover From Fish Oil

Author: Chris Masterjohn, PhD June 24, 2023 Duration: 44:23

Iris from Denmark has generously donated an hour of her consulting time with me to you, the community, so that her case can be used to raise awareness of the importance of arachidonic acid and the pitfalls of getting too much EPA.

In this podcast, we cover:

00:27 Iris's history of too much omega-3 and not enough omega-6.

01:52 The symptoms that have improved upon reversing this.

04:54 Is it correct that the body needs both arachidonic acid and DHA to resolve inflammation?

09:03 How to navigate this during pregnancy, where DHA and AA are both important for the baby but EPA is still a concern?

14:06 Does the body have a storage supply of omega-3?

18:00 What is more important, AA/EPA balance or total PUFA intake? What is more harmful, signaling compound imbalance, oxidative damage, or membrane fluidity distortion?

31:05 Is the proper strategy supplementing AA while reducing EPA, or is it getting more vitamin E?

33:30 What about the ratio of PUFA to saturated fat or total fat?

35:55 Vitamin E cannot protect against all the risks of PUFA. Here are the other things that matter.

41:50 Supporting the marine ecology.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 100

Mastering Nutrition
Podcast Episodes
Self Experiments In the Biochemically Unoptimized State [not-audio_url] [/not-audio_url]

Duration: 3:24:10
Finally, the long-awaited results of my self-experiments conducted from September through January are released! First, make sure you get my MTHFR Protocol, my free 7-page quick guide to optimizing and personalizing your…
My MTHFR Protocol [not-audio_url] [/not-audio_url]

Duration: 0:49
I have a free gift for you. That is my MTHFR Protocol, a 7-page quick guide to optimizing and personalizing your methylation status using foods and supplements. My MTHFR Protocol is free to anyone who subscribes to my Su…
Getting to the Bottom of My Health: Biotin and (V)LCAD [not-audio_url] [/not-audio_url]

Duration: 1:41:09
For nearly 20 years, I have strongly suspected that I have a genetic disorder in synthesizing or recycling something that is absent or poorly available from plant foods, is very rich in organ meats, and is not present in…
Phosphatidylcholine and TMAO | Masterjohn Q&A Files #312 [not-audio_url] [/not-audio_url]

Duration: 21:55
Question: If I'm at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement? Short Answer: On a scale of one to ten, my concern about TMAO and cardiovascular disease is a three. Ther…
Does Erythritol Cause Heart Disease? [not-audio_url] [/not-audio_url]

Duration: 48:37
This analysis of the recent study by the Hazen group at Cleveland Clinic published in Nature Medicine claiming erythritol contributes to cardiovascular disease shows the following: Why elevated plasma erythritol is likel…
Low Blood Sugar on Vegan Keto | Masterjohn Q&A Files #311 [not-audio_url] [/not-audio_url]

Duration: 15:22
Question: How do I fix low blood sugar on vegan keto? Short Answer: Consider how important it is for your ketones to be elevated. Most likely you need to eat more protein, which will lower your ketones. I would aim for a…
Brain Fog on Calcium, Vitamin D, or K2 | Masterjohn Q&A Files #310 [not-audio_url] [/not-audio_url]

Duration: 25:04
Question: Why would vitamin D, vitamin K2, and calcium give me brain fog? Short Answer: Most likely by decreasing serum phosphorus. The solution is to balance these nutrients with vitamin A and phosphorus. This is a clip…