If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? | Masterjohn Q&A Files #317

Question: If a person has a hereditary weakness for Branched Chain Amino Acid Catabolism would this impact the type of diet they might choose to loose weight? Should they limit protein if it will increase their need for nutrients like Biotin?What are all the possible cofactors we should consider supplementing to support Leucine catabolism?

Short Answer: Metabolizing branched-chain amino acids requires all B vitamins except folate, calcium, magnesium, potassium, and chloride. If you have a genetic impairment in this pathway, then reducing branched-chain amino acid intake and doubling down on cofactors is important during weight loss because the pathway will be stressed more in the catabolic state.

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In that batch of free episodes you will also find the answers to these questions:

• Can plant foods and their phytochemicals be used to reduce arterial plaque?

• How do I consume omega-3 without hurting my omega-6 status?

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This snippet is from the January 21, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:

• Can plant foods and their phytochemicals be used to reduce arterial plaque?

• How do I consume omega-3 without hurting my omega-6 status?

• Could carnitine help a fatty acid oxidation disorder?

• Should anti-inflammatories be taken away from workouts?

• How does vitamin C affect autoimmune disease?

• Folate form and purines

• Can methylene blue help the respiratory chain?

• Best references for omega-3 and inflammation resolution?

• Smoothies and blood sugar

• Is transdermal magnesium oil effective for osteoarthritis?

• Why do K2 and Mg help my nerve pain?

• Should I separate my potassium benzoate and vitamin C supplements?

• The best and most simple comprehensive micronutrient panel.

• How much K2 is needed in pregnancy?

• How do I accentuate the fasting-feeding cycle?

• Could K2 help with environmental pollution?

• Why do shoulders crack when we get older?

• Why do I react poorly to anti-inflammatory foods?

Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-january 

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.