Mastering Nutrition
Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite of an apple. It requires the preponderance of signaling.
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This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:
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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.