What to Do About MTHFR | Chris Masterjohn Lite #33

What to Do About MTHFR | Chris Masterjohn Lite #33

Author: Chris Masterjohn, PhD December 6, 2017 Duration: 8:44

Got MTHFR? I got you: here's what you can do with nutrition to optimize for your genetics.

MTHFR mutations increase your need for choline and glycine. It's key to get methylfolate in your diet, but high-dose methylfolate supplements are not the solution. You need to boost choline as an alternative supply of methyl groups, and creatine supplementation can help you better conserve your methylfolate by reducing the need to use it. This is important because adequate methylfolate preserves glycine and prevents it from being lost. Too little protein hurts methylation, but too much worsens the loss of glycine, so you need to hit the Goldilocks amount. Finally, you need to get more glycine to make up for whatever you're losing.

In this episode, I explain how to use food and supplements to make all this work in your favor.

To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Mathew Crawford: Fraud in the Military's Health Database? [not-audio_url] [/not-audio_url]

Duration: 2:17:34
In this interview, Mathew Crawford walks me through his slide presentation of data showing that, at some point between 2020 and 2021, the 2016-2019 data from the US Military's health database was altered in a way that hi…
Nutrition in Neuroscience Part 2 | Mastering Nutrition #41 [not-audio_url] [/not-audio_url]

Duration: 1:39:04
Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your men…
A New Paradigm for Severe COVID [not-audio_url] [/not-audio_url]

Duration: 1:10:46
This new model I developed explains how the depletion of arginine and tryptophan and the sequestration of cysteine leads to T cell suppression in severe COVID and may reflect the rapid onset of a somewhat cancer-reminisc…
Can Regenerative Agriculture Solve the Food Crisis? [not-audio_url] [/not-audio_url]

Duration: 1:32:48
Rising Food Prices Part 4: Can Regenerative Agriculture Solve the Food Crisis? This is the 4th in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going…
Rising Food Prices Part 3: The Commodity Trade [not-audio_url] [/not-audio_url]

Duration: 46:43
Tony Greer joins me to talk about how lockdowns, politics, and the commodity trade contribute to rising food prices. Tony Greer is partly responsible for my awareness of the emerging food crisis as I had initially learne…
Rising Food Prices Part 2: "Money Printing" [not-audio_url] [/not-audio_url]

Duration: 1:07:22
With Dr. Michael Howell, PhD. This is the second in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how…
Rising Food Prices Part 1: Oil and Fertilizer [not-audio_url] [/not-audio_url]

Duration: 1:28:54
This is the first in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving…
The Spike Protein As a Pore-Forming Toxin [not-audio_url] [/not-audio_url]

Duration: 55:19
The spike protein pokes holes in cell membranes at concentrations much lower than those achieved with vaccination, contributing to COVID-like illness and mitochondrial damage. But is the J&J immune? This is not medical a…