Why do my urinary B6 markers say I'm deficient if I'm supplementing and my plasma levels are high-normal? | Masterjohn Q&A Files #300

Why do my urinary B6 markers say I'm deficient if I'm supplementing and my plasma levels are high-normal? | Masterjohn Q&A Files #300

Author: Chris Masterjohn, PhD October 10, 2022 Duration: 6:31

Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake.

This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:

https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver

In that batch of free episodes you will also find the answers to these questions:
  • What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR?
  • Reversing Fatty Liver: How Long Does It Take?
  • What if my A1C says I'm diabetic but my CGM says I'm fine?
  • Will reishi, turmeric, or curcumin tank my testosterone?
  • The 3 Phases of Fasting: And How to Get Kicked Out of Each One

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This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:

  • How do I know if my digestive enzymes are helping or hurting?
  • Why does high-dose glycine give me these terrible symptoms?
  • How to know if my magnesium is messing with my calcium?
  • Why do I have vitamin A symptoms when my lab tests are normal
  • What is my favorite web site for finding enzymatic cofactors
  • Potassium citrate vs potassium chloride
  • Major problems with B vitamin supplements
  • Is food sensitivity testing useful?
  • What nutrients might help with dihydropyrimidine dehydrogenase deficiency?
  • Does lipoic acid hurt methylation?
  • Sulfur SIBO that just won't go away.
  • Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio.
  • Helping bile flow without pharmaceuticals.
  • Managing pernicious anemia.
  • Do we really need to meet the RDA for calcium?
  • Could stretch marks be a sign of copper toxicity?
  • When iron saturation is driven by low binding capacity.
  • How do I know if I need methyl-free Bs?
  • What causes heat intolerance?

    Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 100

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