Why would ferritin be extremely high when transferrin saturation is low? | Masterjohn Q&A Files #140

Why would ferritin be extremely high when transferrin saturation is low? | Masterjohn Q&A Files #140

Author: Chris Masterjohn, PhD November 19, 2020 Duration: 10:43

Question: Why would ferritin be extremely high when transferrin saturation is low?

Ferritin as a potential indicator of iron overload should not be anywhere near the level that was set to try to rule in biopsy provable hemochromatosis that is just a profoundly negligent approach to setting the range for ferritin. Now, I think part of what has stopped, you know— This mostly is a problem of the binary diagnostic mindset of conventional medicine. So, I'm not saying that this mindset is not useful. It is tremendously useful, but too many people confuse it for a reality when in fact it is a reality distortion filter meant to more efficiently triage people through various treatments or nontreatments.

It may be inflammation as you very well tried to feather out. And if it's not that, it's probably oxidative stress. So, I'm not gonna say that's the only other thing it could be. And for the record, you cannot rule out hemochromatosis genetics with 23andMe or any other genetic test by anyone because there are a small percentage of hemochromatosis genetics that are not in the HFE genes and no one has a panel for them. And so, it's improbable that it's hemochromatosis based on 23andMe. You can't rule it out, but I would say it's probably not hemochromatosis because his iron is low. And so, you know, I'm highly suspicious of oxidative stress, which also upregulates ferritin. If you have Testing Nutritional Status: The Ultimate Cheat Sheet, I would measure everything in the oxidative stress section.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
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