533: Biohacking Gone Wrong: Why Everything You're Doing to Optimize Your Health Might Be Backfiring with Dr. Sabrina Solt

533: Biohacking Gone Wrong: Why Everything You're Doing to Optimize Your Health Might Be Backfiring with Dr. Sabrina Solt

Author: Natalie Jill June 23, 2026 Duration: 1:12:30

What if the supplements you've been taking to feel better are actually the reason you feel worse?

That's exactly what happened to me, and it sent me down a rabbit hole that led to one of the most important conversations I've had about my own health. Today I'm sitting down with my close friend and personal doctor, Dr. Sabrina Solt, a regenerative medicine physician and peptide expert who has been in this field for over a decade.

We start with the question that started everything for me: why was I wired at 3am, crashing every afternoon, and reacting to the exact supplements I thought were helping? Dr. Solt breaks down the cortisol-prolactin connection that most doctors never test for, explains why elevated cholesterol in midlife women is often a protective response rather than a red flag, and walks us through the inflammation markers that actually tell the full story of what's happening inside the body.

Then we go deep on what she calls the upstream-downstream problem, the real reason why things like methylated B vitamins, NAD drips, and glutathione pushes can backfire so badly in certain women, and what to do instead. She explains the genetic piece around MTHFR and COMT variations, why "more" is rarely the answer, and what supporting downstream clearance actually looks like in practice.

From there, we get into peptides. Dr. Solt gives a grounded, clinical breakdown of BPC-157, TB-500, KPV, the copper peptide GHKCU, growth hormone releasing peptides, and the serious cautions around GLP microdosing gone wrong. She also shares her vision for what medicine could look like if doctors were equally fluent in peptides and pharmaceuticals.

This is the conversation I've been wanting to bring to you for a long time. Dr. Sabrina Solt is one of the most precise and brilliant minds I know, and she does not hold back.

 

WE GO DEEP ON: 

  • The cortisol-prolactin connection most doctors never test

  • Why high cholesterol isn't always the villain (and what MPO reveals)

  • The upstream-downstream mistake making "healthy" habits backfire

  • Why NAD and glutathione drips can be dangerous for some people

  • A no-BS peptide breakdown: BPC-157, TB-500, KPV, copper peptides, and more

  • The truth about GLP microdosing and its risks

  • What to fix before you ever try a peptide

 

Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube

 

Learn More About Sabrina Solt 

Instagram ➜ http://www.instagram.com/drsolt 

Website ➜ http://www.stemcelltherapypro.com/ 

Peptide Membership Website ➜  https://dr-solts-peptide-corner.circle.so/forms/dfdcc2cd 

 

 

 

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Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen. 

Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.

 


Navigating the changes that come after forty can feel like uncharted territory, but Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40 offers a grounded and practical companion for the journey. Hosted by Natalie Jill, this podcast cuts through the overwhelming noise surrounding health and fitness specifically for women in this vibrant life stage. You’ll hear honest discussions about the very real shifts in metabolism, energy, and hormones that impact weight and well-being, moving beyond generic advice to strategies that actually work for a changing body. Natalie has a knack for translating complex science into clear, actionable steps, whether she’s explaining the nuances of cortisol and estrogen or sharing a sustainable approach to nutrition. The conversations extend beyond fat loss to encompass a fuller picture of health, including mindset, stress management, and reclaiming vitality. Alongside her solo episodes, Natalie brings in inspiring voices-women and experts who are thriving in their own midlife chapters-to share diverse perspectives and real-world success stories. This isn’t about quick fixes; it’s about building a sustainable, empowered lifestyle for your best years ahead. Tune in for a blend of relatable storytelling, grounded expertise, and the tangible tools you need to feel strong, confident, and in control of your health during midlife and beyond.
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