How Unlocking The Secrets Of Nano Vaults Could Revolutionize Disease Cures

How Unlocking The Secrets Of Nano Vaults Could Revolutionize Disease Cures

Author: Don Murphy May 13, 2025 Duration: 1:00:17

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This episode explores the mystery of a cellular organelle known as the vault and how unlocking the secrets of nano vaults could revolutionize Disease Cures.  Though its structure is well know and its protein composition well established, its function remains a mystery.  Joining us to explain this mystery is its discoverer, Dr. Leonard Rome.

Dr. Leonard H. Rome is a cell biologist, biochemist and part-time dean involved in research, teaching and administration at the University of California, Los Angeles. He earned his undergraduate degree (B.S. in Chemistry) and graduate degrees (M.S. and Ph.D. in Biological Chemistry) at the University of Michigan, Ann Arbor. He was a postdoctoral fellow at the National Institutes of Health, where he worked on lysosome biogenesis.

Dr. Rome has been on the faculty of the David Geffen School of Medicine at UCLA since he joined the Department of Biological Chemistry in 1979. He became a full Professor in 1988 and has been Senior Associate Dean for Research in the School of Medicine since 1997. Since 2005 he has been the Associate Director of the California NanoSystems Institute. Dr. Rome has served as the elected Chair of the School of Medicine Faculty Executive Committee and he is actively involved in Graduate and Medical Education. In 1991 he received a UCLA School of Medicine Award for Excellence in Education.

If you would like to learn more about vaults check out Dr. Rome's youtube channel or go to our website:


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Don Murphy hosts Nature and Science Podcast, a series built on conversations with people for whom curiosity is a way of life. Rather than presenting dry lectures, each episode unfolds as a personal narrative, tracing the unique path that led a guest to their particular corner of the natural or scientific world. You might hear a theoretical physicist describe the moment a complex equation first felt beautiful, or a park ranger recount the specific, quiet morning that solidified their commitment to a wilderness area. The discussions are grounded in the human experience behind the disciplines, whether it's a conservation biologist explaining the emotional weight of tracking a species' recovery or an amateur astronomer sharing how mapping the stars became a lifelong solace. This approach makes the vast subjects of nature and science feel accessible and intimately connected to daily life. By focusing on these individual journeys, the podcast reveals how passion and profession intertwine, offering listeners not just information, but inspiration. It’s for anyone who has ever looked at a forest or a formula and wondered about the stories hidden within. Tune in to find a sense of connection through the shared wonder of exploration.
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