AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus

AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus

Author: Conviction April 3, 2026 Duration: 29:25
What happens when you apply the scaling laws of large language models to the physical work of atoms? Elad Gil sits down with Liam Fedus, co-founder at Periodic Labs, which is pioneering an AI foundation lab for atoms. Liam discusses how he pivoted from dark matter physics research to the front lines of artificial intelligence, including stints at Google Brain and working on ChatGPT at OpenAI. He talks about how Periodic is connecting massive language models to the physical world to overcome data bottlenecks in material science. Liam also shares how they use language models as an orchestration layer operating alongside specialized neural nets to run closed-loop physical experiments. They also explore the future of AGI and ASI, as well as the role of robotics in lab automation. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @LiamFedus | @periodiclabs Chapters: 00:00 – Cold Open 00:05 – Liam Fedus Introduction 00:39 – Liam’s Background at Google Brain, OpenAI 05:14 – From ChatGPT to Materials and Atoms 06:34 – Training Data in the Physical World 09:52 – Generalization Across Domains 11:31 – Models as an Orchestration Layer 12:48 – Commercialization and Business Model 16:10 – How Periodic’s Success May Shape the Future  17:45 – Multidisciplinary Scaling 19:41 – Capital and Compute 21:12 – Hiring at Periodic 21:44 – Thoughts on AGI and ASI 23:30 – Timeline for Machine-Directed Self-Improvement 25:39 – Automation and Data Generation 27:59 – Why Liam is Excited About the Future of Robotics 29:25 – Conclusion

Elad Gil and Sarah Guo guide conversations in No Priors: Artificial Intelligence | Technology | Startups that cut straight to the core of what's happening now. This isn't about abstract futures; it's grounded in dialogues with the very people building and shaping the field-leading AI engineers, pioneering researchers, and the founders turning theory into reality. Each episode tackles the pressing, often daunting questions that define this technological inflection point. You'll hear them explore the practical pathways and hurdles toward AGI, debate which industries are genuinely poised for transformation, and examine how the state-of-the-art in research translates into real-world products and societal shifts. The discussions naturally span the impact on commerce, culture, and the very structure of how we live and work. Produced by Conviction, this podcast serves as an essential, clear-eyed resource for anyone looking to move beyond the hype and understand the forces driving the AI revolution. Sarah Guo, a startup investor, and Elad Gil bring their direct experience to these conversations, ensuring every interview provides substantive insight you can use.
Author: Language: English Episodes: 100

No Priors: Artificial Intelligence | Technology | Startups
Podcast Episodes
Gaming, Nobel Prizes and At-Risk Businesses in the AI Era [not-audio_url] [/not-audio_url]

Duration: 29:29
In this episode of No Priors, Sarah and Elad explore how AI is transforming consumer apps and entertainment, with a focus on potential integrations in gaming and dating that could shift traditional societal incentives. T…
Launching AI products with Braintrust’s CEO Ankur Goyal [not-audio_url] [/not-audio_url]

Duration: 38:28
Today on No Priors, Elad is joined by Ankur Goyal, founder and CEO of Braintrust. Braintrust enables companies like Notion, Airtable, Instacart, Zapier, and Vercel to deploy AI solutions at scale by efficiently evaluatin…
The Road to Autonomous Intelligence with Andrej Karpathy [not-audio_url] [/not-audio_url]

Duration: 44:16
Andrej Karpathy joins Sarah and Elad in this week of No Priors. Andrej, who was a founding team member of OpenAI and former Senior Director of AI at Tesla, needs no introduction. In this episode, Andrej discusses the evo…
Cloud Strategy in the AI Era with Matt Garman, CEO of AWS [not-audio_url] [/not-audio_url]

Duration: 42:58
In this episode of No Priors, hosts Sarah and Elad are joined by Matt Garman, the CEO of Amazon Web Services. They talk about the evolution of Amazon Web Services (AWS) from its inception to its current position as a maj…