RHR: Revisiting the Gut-Immune Axis

RHR: Revisiting the Gut-Immune Axis

Author: Chris Kresser May 12, 2026 Duration: 26:11

The gut-immune axis is one of the most important and most overlooked systems in human health. In this episode of Revolution Health Radio, Chris explains how the gut microbiome, intestinal barrier, and immune system work together to regulate inflammation and protect against disease. Learn how disruptions in gut health, driven by ultra-processed foods, environmental toxins, antibiotics, and chronic stress, can lead to intestinal permeability, chronic immune activation, and a wide range of conditions including autoimmune disease, skin disorders, respiratory illness, and metabolic dysfunction. Chris also breaks down the latest research on key compounds that support gut and immune health, including probiotics, prebiotics, butyrate, polyphenols, colostrum, lactoferrin, and beta glucan. Discover how targeted nutrition and lifestyle strategies can restore gut integrity, improve immune resilience, and address the root cause of chronic illness.

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Tired of health advice that feels one-size-fits-all or contradicts what you heard last week? Revolution Health Radio cuts through the noise with a different approach. Hosted by health detective Chris Kresser, this podcast digs into the often overlooked root causes of modern chronic conditions, moving beyond just treating symptoms. Each episode is a deep, evidence-informed conversation that challenges conventional wisdom on diet, fitness, and wellness. You’ll hear detailed explorations on topics like metabolic health, gut microbiome science, and sustainable fitness practices, all framed around actionable strategies for real life. Kresser translates complex research into practical steps, empowering you to make informed decisions about your own well-being. Rather than offering quick fixes, this podcast builds a foundational understanding of how the body works, aiming for lasting vitality. It’s for anyone who feels let down by mainstream narratives and is curious about the nuanced, sometimes alternative, paths to preventing illness and optimizing health. Tune in for thoughtful dialogues that equip you with the knowledge to take true ownership of your health journey.
Author: Language: en-us Episodes: 43

Revolution Health Radio
Podcast Episodes
RHR: The Longevity Trap: Why Chasing Anti-Aging May Be Aging You [not-audio_url] [/not-audio_url]

Duration: 15:58
In this episode, Chris explains why obsession with anti-aging hacks may actually undermine our long-term health. He examines the common longevity traps people fall into, which foundational habits truly extend lifespan an…
RHR: The Science Behind Oral Inflammation, with Dr. William Levine [not-audio_url] [/not-audio_url]

Duration: 41:39
In this episode of Revolution Health Radio, Chris welcomes board-certified periodontist Dr. William Levine to discuss the overlooked role of gum health in systemic disease. They unpack how oral bacteria and chronic infla…
RHR: The Nourishment Table, with Frederic Leroy [not-audio_url] [/not-audio_url]

Duration: 1:05:34
In this episode of Revolution Health Radio, Chris Kresser welcomes food scientist and advocate for regenerative agriculture Dr. Frederic Leroy to discuss his groundbreaking work on the Nourishment Table, a new framework…
RHR: Everything You Need to Know About Collagen [not-audio_url] [/not-audio_url]

Duration: 1:07:35
In this episode of Revolution Health Radio, Chris Kresser dives deep into the fascinating world of collagen, the most abundant protein in the human body. He explores collagen's wide-ranging benefits—from supporting vibra…