RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health

RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health

Author: Chris Kresser February 24, 2026 Duration: 29:46

Depression and anxiety are often treated as chemical imbalances in the brain—but what if the real problem starts in the gut? In this episode of Revolution Health Radio, we dive deep into the gut–brain connection and the growing body of research linking gut inflammation, microbiome imbalance, and mood disorders. You’ll learn how inflammatory cytokines contribute to depression, why butyrate is emerging as a powerful antidepressant compound, and how specific probiotic strains can improve mental health outcomes. Chris also shares practical, evidence-based strategies—including diet, supplementation, and functional testing—to address root causes and support lasting emotional well-being.

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Tired of health advice that feels one-size-fits-all or contradicts what you heard last week? Revolution Health Radio cuts through the noise with a different approach. Hosted by health detective Chris Kresser, this podcast digs into the often overlooked root causes of modern chronic conditions, moving beyond just treating symptoms. Each episode is a deep, evidence-informed conversation that challenges conventional wisdom on diet, fitness, and wellness. You’ll hear detailed explorations on topics like metabolic health, gut microbiome science, and sustainable fitness practices, all framed around actionable strategies for real life. Kresser translates complex research into practical steps, empowering you to make informed decisions about your own well-being. Rather than offering quick fixes, this podcast builds a foundational understanding of how the body works, aiming for lasting vitality. It’s for anyone who feels let down by mainstream narratives and is curious about the nuanced, sometimes alternative, paths to preventing illness and optimizing health. Tune in for thoughtful dialogues that equip you with the knowledge to take true ownership of your health journey.
Author: Language: en-us Episodes: 35

Revolution Health Radio
Podcast Episodes
RHR: The Longevity Trap: Why Chasing Anti-Aging May Be Aging You [not-audio_url] [/not-audio_url]

Duration: 15:58
In this episode, Chris explains why obsession with anti-aging hacks may actually undermine our long-term health. He examines the common longevity traps people fall into, which foundational habits truly extend lifespan an…
RHR: The Science Behind Oral Inflammation, with Dr. William Levine [not-audio_url] [/not-audio_url]

Duration: 41:39
In this episode of Revolution Health Radio, Chris welcomes board-certified periodontist Dr. William Levine to discuss the overlooked role of gum health in systemic disease. They unpack how oral bacteria and chronic infla…
RHR: The Nourishment Table, with Frederic Leroy [not-audio_url] [/not-audio_url]

Duration: 1:05:34
In this episode of Revolution Health Radio, Chris Kresser welcomes food scientist and advocate for regenerative agriculture Dr. Frederic Leroy to discuss his groundbreaking work on the Nourishment Table, a new framework…