Denis Noble: The Failure of The Gene-Centric Paradigm

Denis Noble: The Failure of The Gene-Centric Paradigm

Author: Cameron Borg August 17, 2026 Duration: 1:47:29

Denis Noble is a world-renowned British biologist most well known for his contributions to systems biology. During his time as a Professor of Cardiovascular Physiology and Emeritus Professor of Computational Physiology at Oxford, Denis pioneered the use of novel, nonlinear models of physiology that see the phenomena of emergence as fundamental, rather than a mere curiosity. He has been an outspoken critic of the gene-centric approach to health and disease that has remained orthodoxy since the discovery of the double helix by Watson and Crick in the 1950s.

With complex, living systems endowed with the capacity of dynamic self-organisation, Noble argues that genes cannot cause disease, as they are embedded within a set of interactions between the organism and its environment; relationships that contextualise the transcription of genes. Rather than viewing genes as determinants of outcomes, they are merely part of a chain of interactions where information flows from the environment to the highly flexible organism.

Please consider subscribing to my Substack where I share my detailed thoughts and insights on my podcast topics and beyond. This is the best way to support me and the podcast. https://ricciflow.substack.com/

Follow Aastha

Follow Me


Hosted by Cameron Borg, Ricci Flow Nutrition Podcast digs into the core principles that sustain our well-being, moving beyond fleeting trends to examine what truly supports a healthy life. Each conversation is built on the idea that lasting vitality comes from a deep understanding of foundational habits, from how we nourish our bodies to how we structure our daily movement. This isn't about quick fixes or rigid rules, but rather about exploring the underlying science and practical wisdom that can be adapted to any lifestyle. You'll hear thoughtful discussions that connect nutrition to broader aspects of fitness and holistic health, always with an eye on sustainable, evidence-based approaches. Tuning into this podcast feels like getting a clear-eyed, grounded perspective in a world full of health noise, offering actionable insights that help you build a more resilient version of yourself from the ground up.
Author: Language: English Episodes: 50

Ricci Flow Nutrition Podcast
Podcast Episodes
Jack Kruse: Mate Selection, DNA, Bioelectricity & Thermodynamics [not-audio_url] [/not-audio_url]

Duration: 2:08:22
Jack Kruse is a practising neurosurgeon with particular interest and expertise in quantum biology. In our previous podcast episode, Jack and I focused on the pillars that lay the foundation for all life on Earth; light,…
Eyla Cuenca: Conscious Conception, Pregnancy & Birth [not-audio_url] [/not-audio_url]

Duration: 1:12:46
Eyla Cuenca is a holistic birth guide, Childbirth Educator, Doula, health freedom advocate and birth trauma alchemist. She holds a BA in Anthropology and Ethnographic photography from Bennington College. After working as…
Leland Stillman: Medicine, Trauma & Upholding The Hippocratic Oath [not-audio_url] [/not-audio_url]

Duration: 1:09:06
Leland Stillman, MD is an American integrative medical doctor who specialises in environmental medicine. Leland realised very early on in his career that conventional medical practices focus on symptom management rather…
Jim Laird: Embracing The Fundamentals & Simplicity [not-audio_url] [/not-audio_url]

Duration: 1:14:07
Jim Laird, an experienced strength and conditioning and health coach. Since 1997, he has empowered clients from diverse backgrounds to achieve their goals. From everyday individuals to professional athletes in the NFL, C…
Clark Engelbert: Mineral Balancing & Systems Biology [not-audio_url] [/not-audio_url]

Duration: 1:25:50
Clark is a health practitioner who specialises in mineral balancing. The concept of mineral balancing is based on the field of ionomics and stems from the work of a soil scientist, William Albrecht. Clark is particularly…
Cyndi O'Meara: Vitalism as a Guide to Health & Wellness [not-audio_url] [/not-audio_url]

Duration: 1:03:34
Cyndi O’Meara is a leading nutritionist, filmmaker, best-selling author, TEDx Speaker and Founder of Changing Habits and The Nutrition Academy. She has been a trailblazer in the natural health space for several decades.…
Michael Holick: Vitamin D & Leveraging Sunlight For Health [not-audio_url] [/not-audio_url]

Duration: 58:44
Michael Holick, MD, PhD, is an American endocrinologist and world’s leading expert on Vitamin D. He is known for his discovery of the active form of Vitamin D and the development of the assay for the circulating form - o…
Gaétan Chevalier: Earthing & Bioelectromagnetism [not-audio_url] [/not-audio_url]

Duration: 1:21:08
Gaétan Chevalier, PhD, is an expert in engineering physics, atomic physics and laser spectroscopy. He is a world-leading expert on the effects of earthing (otherwise known as grounding) on human biology. Gaetan has been…