#443: Kevin Klatt, PhD, RD - Can Choline Help Improve DHA Status?

#443: Kevin Klatt, PhD, RD - Can Choline Help Improve DHA Status?

Author: Danny Lennon June 22, 2022 Duration: 1:11:19
A recently published study by Klatt and colleagues examined the impact of choline supplementation alongside DHA supplementation, versus DHA supplementation alone, on DHA status in pregnancy.

It is known that DHA is a critical nutrient at this time for healthy development of the child. And through a number of mechanisms discussed later, it has been hypothesized that choline could lead to greater DHA status.

We discuss:
  • What is the connection between choline and DHA? What is the PEMT pathway?
  • Study design for the choline + DHA trial
  • Are there risks of high-dose choline?
  • Main findings of the trial
  • How DHA status is not just a function of DHA intake, but also methyl metabolism too
  • Issues with omega-3 trials; e.g. not taking baseline status into account
  • Pragmatic recommendations for health professionals and patients
  • Different forms of choline supplements
  • Choline supplementation vs. food-derived choline
 

Sigma Nutrition Radio, hosted by nutrition scientist Danny Lennon, moves beyond the noise of diet trends and simplistic advice to explore the complex, fascinating world of human nutrition. This is a space for deep, evidence-based conversations that acknowledge the nuance and often contradictory nature of scientific research. Each episode delves into a specific topic within health, fitness, or dietetics, breaking down the underlying physiology, examining the latest studies, and discussing practical implications with expert guests. The goal isn't to hand out rigid meal plans but to cultivate the critical thinking skills necessary to navigate the ever-changing landscape of nutritional science. You'll hear detailed analyses of how research is conducted, thoughtful debates on contentious issues, and explorations of how evidence translates-or doesn't-into real-world recommendations for different individuals. Tuning into this podcast means committing to a more sophisticated understanding of how food, movement, and metabolism interact, leaving you better equipped to make informed decisions about your own health and skepticism towards the next big headline. Danny’s approach is both rigorous and accessible, making even the most detailed biochemical pathways relevant to everyday life. It’s for anyone who has ever wondered about the real story behind a nutrition claim and values substance over soundbites.
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