#537: Appetite Regulation, Metabolic Compensation and More – Stephan Guyenet, PhD

#537: Appetite Regulation, Metabolic Compensation and More – Stephan Guyenet, PhD

Author: Danny Lennon October 1, 2024 Duration: 1:04:07

This is an "ask me anything" (AMA) episode with Dr. Stephan Guyenet, an expert in obesity neuroscience and eating behavior. This episode was originally published on Sigma Nutrition Premium. If you're interested in subscribing to Sigma Nutrition Premium, then check all the details here.

Questions Answered:

  1. [04.27] If we surgically remove adipose tissue, do leptin levels suddenly drop? How would this impact hunger over time?
  2. [06.56] How does chronic energy restriction (or following a crash diet) affect long-term appetite regulation?
  3. [13.21] How do anorexia and pronounced obesity defy the rules of metabolic compensation?
  4. [24.12] Why do some SDRIs (serotonin–dopamine reuptake inhibitors) reduce hunger/appetite?
  5. [28.02] Can an algorithm really decipher someone's "ideal weight?
  6. [33.08] Could the "brain microbiome" impact appetite regulation and/or obesity?
  7. [35.34] In our current environment, are the only efficacious interventions drugs and bariatric surgery?
  8. [46.01] What should we make of claims by Gary Taubes about insulinogenic foods?
  9. [52.37] Is there a maximum duration someone should spend in fat loss (or weight gain) phases?
  10. [53.43] Why do some people struggle to gain weight?

Links:


Sigma Nutrition Radio, hosted by nutrition scientist Danny Lennon, moves beyond the noise of diet trends and simplistic advice to explore the complex, fascinating world of human nutrition. This is a space for deep, evidence-based conversations that acknowledge the nuance and often contradictory nature of scientific research. Each episode delves into a specific topic within health, fitness, or dietetics, breaking down the underlying physiology, examining the latest studies, and discussing practical implications with expert guests. The goal isn't to hand out rigid meal plans but to cultivate the critical thinking skills necessary to navigate the ever-changing landscape of nutritional science. You'll hear detailed analyses of how research is conducted, thoughtful debates on contentious issues, and explorations of how evidence translates-or doesn't-into real-world recommendations for different individuals. Tuning into this podcast means committing to a more sophisticated understanding of how food, movement, and metabolism interact, leaving you better equipped to make informed decisions about your own health and skepticism towards the next big headline. Danny’s approach is both rigorous and accessible, making even the most detailed biochemical pathways relevant to everyday life. It’s for anyone who has ever wondered about the real story behind a nutrition claim and values substance over soundbites.
Author: Language: English Episodes: 620

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