Bills vs Saints Preview & Bold Predictions

Bills vs Saints Preview & Bold Predictions

Author: Blue Wire September 26, 2025 Duration: 38:31

On this episode of Talking Buffalo, Patrick Moran has a preview of the Buffalo Bills week four tilt against the New Orleans Saints at Highmark Stadium this coming Sunday, including keys to the game for Buffalo, five bold predictions and a stab at the final score.

The Saints have won four straight in Orchard Park and haven't lost to the Bills on the road since 1983. Spoiler alert--that's highly likely to change. Buffalo comes into this game at least 15.5 point favorites and a little more on other betting sites for good reasons. The Bills are undefeated and one of if not the most complete team in the NFL whereas New Orleans comes stumbling in winless, with a "shaky" quarterback situation and no real team identity.

Patrick spends some time catching Buffalo fans up to the Saints, the good, bad (plenty) and ugly (also plenty). That said, this is the NFL and anything can happen and Patrick runs down three keys for the Bills ensuring they stay undefeated heading into a prime time divisional home game matchup against New England the following week.

Five bold predictions for the games are also offered, including an old veteran getting an interception, a breakout game for a defender who should've already had one by now and a good game ins tore for a depth skilled position player. That plus we all know Patrick's not picking against the Bills when they're playing the Saints---but does he like Buffalo to cover the spread? That and plenty more.

The Talking Buffalo online merch store is now live! You can purchase t shirts, hoodies, zip ups, crewnecks and polos in a couple of different styles and colors. Visit our online page for pricing and options and while there, check out Buf on Weck for tons of cool gear!

Major props to Talking Buffalo sponsor, Sonny Red’s at 1841 Abbott Road in Lackawanna, just minutes from Highmark Stadium. We consider them THE most underrated spot for wings, pizza and other great food in Western New York plus it’s a great place to drink and have a great time. Also big thanks to Imperial Pizza and their two locations (1035 Abbott Road and 1655 Main Street), home of not only great pizza and tons of other delicious eats but also the best everyday lunch special in town.

♦♦♦♦♦

Follow Patrick Moran/Talking Buffalo Podcast 

Substack: Patrick Moran’s Substack

Twitter: @PatrickMoranTB

Blue Sky: @PatrickMoranTB.bsky.social

Instagram: @PatrickMoranTB

Facebook: Talking Buffalo Podcast 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


There's a particular kind of passion that comes from following Buffalo sports, a mix of unwavering hope and hardened realism that Talking Buffalo captures perfectly. Hosted by Buffalo-born Patrick Moran, this Blue Wire podcast dives deep into the heart of the city's teams, with a primary focus on the emotional rollercoasters provided by the Bills and Sabres. Patrick doesn't just report on games; he lives them, offering a perspective that can swing from critical skepticism to full-blown optimism in a single conversation. That authentic, sometimes self-deprecating fan voice is exactly what drives each episode. The show regularly features interviews with guests from across the sports world, media, and even pop culture, providing unique angles and insider insights you won't find elsewhere. It’s this blend of local passion, candid analysis, and diverse conversations that gives the podcast its character. You'll hear the highs, the lows, and all the gritty commentary in between, all filtered through the experience of someone who truly understands what it means to invest in these teams. For anyone who bleeds blue and red or simply appreciates the complex narrative of a sports city, Talking Buffalo feels like a conversation with a knowledgeable, and admittedly opinionated, friend.
Author: Language: English Episodes: 1000

Talking Buffalo
Podcast Episodes
Why Brandin Cooks Proved The Brady Naysayers Wrong [not-audio_url] [/not-audio_url]

Duration: 41:47
On this Saturday episode of Talking Buffalo, Patrick Moran hosts a Podbag episode chockfull of listener submitted questions and takes centering around the Buffalo Bills, including discussing why 32-year old journeyman wi…
Takeaways From An Impressive Jim Leonhard Bills Press Conference [not-audio_url] [/not-audio_url]

Duration: 38:21
On this episode of Talking Buffalo, Patrick Moran shares some of his biggest takeaways after new Buffalo Bills defensive coordinator Jim Leonhard met with the media on Thursday, including coming up with a boxing comparis…
Bills Final Season Positional Analysis & Grades [not-audio_url] [/not-audio_url]

Duration: 1:04:43
On this episode of Talking Buffalo, Patrick Moran is joined by Matt Warren from SB Nation to go over the Buffalo Bills 2025 season positionally, followed by Matt's final season-long grades for all areas of the team in an…
Five Huge Questions Brandon Beane Must Answer [not-audio_url] [/not-audio_url]

Duration: 41:05
On this episode of Talking Buffalo, Patrick Moran goes over five of the biggest questions that Buffalo Bills general manager (and President of Operations) Brandon Beane is going to have answer soon as he starts to constr…
What A Jim Leonhard Bills Defense May Look Like [not-audio_url] [/not-audio_url]

Duration: 1:26:27
On this episode of Talking Buffalo, Patrick Moran is joined by Cover 1's Anthony Prohaska to discuss several Buffalo Bills topics, including new defensive coordinator Jim Leonhart and what his defense may look like for t…
Joe Brady Presser Reaction: Color Me Impressed [not-audio_url] [/not-audio_url]

Duration: 1:08:13
On today's Talking Buffalo, new Buffalo Bills head coach Joe Brady's introductory press conference took place on Thursday and Patrick Moran has a boatload of reactions, including why he came away from it surprisingly (ve…
Sabres On The Warpath! (Featuring Joe Yerdon Live From Sonny Red's) [not-audio_url] [/not-audio_url]

Duration: 1:19:02
On this episode of Talking Buffalo, Patrick Moran is joined by Buffalo Sabres and NHL writer Joe Yerdon to discuss the absolutely scorching hot Buffalo Sabres in addition to a little Buffalo Bills talk as well, recorded…
Bills Promote Brady To Wildly Unpopular Reaction [not-audio_url] [/not-audio_url]

Duration: 38:15
On this episode of Talking Buffalo, Patrick Moran has plenty of instant reaction after the Buffalo Bills promote offensive coordinator Joe Brady to head coach following interviews with several candidates, leaving some pe…
Sabres Tearing Sh*t Up & Favorite Bills HC Candidates [not-audio_url] [/not-audio_url]

Duration: 1:14:49
On this episode of Talking Buffalo, Patrick Moran is joined by broadcaster Steve Bermel to discuss their preferred Buffalo Bills head coaching candidates and a Buffalo Sabres team has been absolutely tearing the league u…