#472 DIGEST: cfDNA & cancer in Pregnancy, Vitamin K2 for Leg Cramps, PRN anti-hypertensives, GLP-1 Agonists for AUD, Short-Course Antibiotics

#472 DIGEST: cfDNA & cancer in Pregnancy, Vitamin K2 for Leg Cramps, PRN anti-hypertensives, GLP-1 Agonists for AUD, Short-Course Antibiotics

Author: The Curbsiders Internal Medicine Podcast February 24, 2025 Duration: 54:24
Join us as we review recent articles and news featured in The DIGEST issues #59-61, including cfDNA and incidental detection of cancer in pregnancy, vitamin K2 for nocturnal leg cramps, the danger of as-needed anti-hypertensive medications in the hospital, GLP-1 agonists for alcohol use disorder, short-course (7 vs 14 days) antibiotics for bacteremia, and patient-collected HPV testing for cervical cancer screening. Fill your brain hole with a fully digestible meal! Featuring Laura Glick MD, Nora Taranto (@norataranto), Paul Williams (@paulnwilliamz), and Matt Watto (@doctorwatto)

Claim CME for this episode at curbsiders.vcuhealth.org!

Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME

Show Segments

  • 00:00 Introduction and Overview
  • 02:57 The IDENTIFY study: Non-Invasive Prenatal Testing and Cancer Detection with cfDNA
  • 05:54 Implications of Non-Reportable Results in Prenatal Testing
  • 08:51 Vitamin K2: A New Approach to Managing Nocturnal Leg Cramps
  • 12:07 Practicality and Future of Vitamin K2 in Clinical Practice
  • 23:21 The Dangers of As-Needed Antihypertensives in the hospital
  • 32:21 Exploring GLP-1 Agonists for Alcohol Use Disorder
  • 40:24 Shorter Antibiotic Courses in Sepsis
  • 46:09 Advancements in Patient-Collected HPV Screening for cervical cancer


Credits

  • Written and Produced by: Nora Taranto MD, Laura Glick MD, Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Show Notes: Nora Taranto MD
  • Cover Art: Matthew Watto MD, FACP
  • Hosts: Nora Taranto MD, Laura Glick MD, Matthew Watto MD, FACP; Paul Williams MD, FACP   
  • Reviewer: Emi Okamoto MD
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Technical Production: PodPaste

Disclosures

The Curbsiders report no relevant financial disclosures. 

Sponsor:
Bombas

Head over to Bombas.com/curb and use code curb for 20% off your first purchase.

Sponsor:
Pretty Litter 

Go to PrettyLitter.com/curb to save twenty percent on your FIRST order and get a free cat toy. 

Sponsor:
Rocket Money 

Cancel your unwanted subscriptions and reach your financial goals faster with Rocket Money. Go to RocketMoney.com/CURB today.



Tune in to The Curbsiders Internal Medicine Podcast for a direct line to practical clinical knowledge and the ever-evolving art of patient care. This isn't a dry lecture series; it's a dynamic conversation among practicing physicians who break down complex topics into actionable insights you can use. Each episode delves into the nuances of internal medicine, from managing common chronic conditions to interpreting the latest guidelines and navigating diagnostic dilemmas. You'll hear honest discussions about challenges at the bedside, evidence-based debates, and expert interviews that go beyond textbook summaries to reveal how medicine works in the real world. The podcast serves as both a continuing education resource and a professional companion, offering thoughtful analysis and clinical pearls that resonate whether you're a seasoned hospitalist, a resident in training, or a primary care provider. The focus is consistently on deepening understanding and improving daily practice, making the rounds or the clinic day feel a little less daunting and a lot more informed. Listen for a blend of curiosity, camaraderie, and a genuine commitment to mastering the craft of medicine, all delivered through engaging dialogue that feels like consulting with a trusted colleague.
Author: Language: English Episodes: 100

The Curbsiders Internal Medicine Podcast
Podcast Episodes
#460 HFpEF: Heart Failure with Preserved Ejection Fraction [not-audio_url] [/not-audio_url]

Duration: 49:39
Preserve your sanity while treating heart failure with preserved ejection fraction. Dr Michelle Kittleson @MKittlesonMD (Cedars Sinai) illuminates this confounding cardiac condition.Claim CME for this episode at curbside…
#458 HFrEF: Heart Failure with Reduced Ejection Fraction [not-audio_url] [/not-audio_url]

Duration: 1:04:24
Kittleson Rules Outpatient Heart Failure Volume 1Provide superb outpatient care for your patients with HFrEF. Identify underlying causes of heart failure and titrate medications with ease. Dr Michelle Kittleson @MKittles…
#457 Cold and Flu Season: Upper Respiratory Infections aka URIs [not-audio_url] [/not-audio_url]

Duration: 1:06:25
Treating colds, flu, and more with Dr Amber Bird! Dive deep into upper respiratory viral infections with Dr Amber Bird, MD (Penn). Feel confident on when to order testing, recommend symptom relieving treatments, and avoi…
#456 Outpatient Oxygen Therapy [not-audio_url] [/not-audio_url]

Duration: 1:12:57
Supplemental oxygen is ubiquitous and yet there is a tremendous amount of uncertainty related to prescription and management in the outpatient setting. Have no fear, we’ve got your back! On this episode of The Curbsiders…
#455 Sports Injuries Part 2: Hip and Knee [not-audio_url] [/not-audio_url]

Duration: 54:04
De-stress your approach to stress fractures (and trochanteric pain syndromes and meniscus tears)!Follow along as the great Dr. Senter guides us through the diagnosis, workup, and treatment of an all-star lineup of sport…
#454 Kidney Boy on Managing Diabetes and Hypertension in CKD [not-audio_url] [/not-audio_url]

Duration: 1:05:55
Learn how to manage diabetes and hypertension in chronic kidney disease with expert tips from Kidney Boy, Kashlak’s Chief of Nephrology, Dr. Joef Topf @kidney_boy. Claim CME for this episode at curbsiders.vcuhealth.org!P…
#453 Sports Injuries Part 1: Concussion and Hip Pain [not-audio_url] [/not-audio_url]

Duration: 57:30
Follow along as the great Dr. Senter guides us through the diagnosis, workup, and treatment of an all-star lineup of sport injuries. Part 1 covers concussions, femoroacetabular impingement (FAI), and the ongoing quest to…
#451 Acute Coronary Syndrome with Dr. Sanjeev Francis - Part 2 [not-audio_url] [/not-audio_url]

Duration: 1:03:39
Quit playing games with my heartYet another beat no to skip here with part 2 of our conversation with cardiologist Dr. Sanjeev Francis (@, Maine Medical Center)for acute coronary syndrome. Learn about the warranty on str…