#508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies

#508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies

Author: The Curbsiders Internal Medicine Podcast December 15, 2025 Duration: 1:35:11
Master cardiovascular disease prevention! Learn how to apply the new PREVENT risk calculator, use the CPR framework for risk reclassification, and interpret ApoB and Lp(a) in modern lipid management. We’re joined by Dr. Laurence Sperling to break down what’s new in ASCVD risk assessment and prevention.

Claim CME for this episode at curbsiders.vcuhealth.org!

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Show Segments

  • Intro
  • Case 1 from Kashlak 
  • Risk assessment framework
  • ApoB and Non-HDL cholesterol
  • Lipoprotein(a) and its importance
  • The PREVENT risk score and its implications
  • Statins and other lipid lowering therapies
  • The role of diet and lifestyle in lipid management
  • Case 2 from Kashlak
  • Familial Hypercholesterolemia diagnosis and management
  • Key takeaways
  • Outro

Credits

  • Producer, Writer, Shownotes, Infographic, and Cover art: Ben Furman, MPH 
  • Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP   
  • Reviewer: Leah Witt, MD
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Technical Production: PodPaste
  • Guest: Laurence Sperling, MD 

Disclosures

Dr. Sperling reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.


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Tune in to The Curbsiders Internal Medicine Podcast for a direct line to practical clinical knowledge and the ever-evolving art of patient care. This isn't a dry lecture series; it's a dynamic conversation among practicing physicians who break down complex topics into actionable insights you can use. Each episode delves into the nuances of internal medicine, from managing common chronic conditions to interpreting the latest guidelines and navigating diagnostic dilemmas. You'll hear honest discussions about challenges at the bedside, evidence-based debates, and expert interviews that go beyond textbook summaries to reveal how medicine works in the real world. The podcast serves as both a continuing education resource and a professional companion, offering thoughtful analysis and clinical pearls that resonate whether you're a seasoned hospitalist, a resident in training, or a primary care provider. The focus is consistently on deepening understanding and improving daily practice, making the rounds or the clinic day feel a little less daunting and a lot more informed. Listen for a blend of curiosity, camaraderie, and a genuine commitment to mastering the craft of medicine, all delivered through engaging dialogue that feels like consulting with a trusted colleague.
Author: Language: English Episodes: 100

The Curbsiders Internal Medicine Podcast
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