#525: Multi-Cancer Early Detection Testing

#525: Multi-Cancer Early Detection Testing

Author: The Curbsiders Internal Medicine Podcast May 18, 2026 Duration: 48:58

Cut through the hype of Multi-Cancer Early Detection (MCED) tests and learn how to counsel patients on the real-world utility, false-positive risks, and the "stage shift" debate of these emerging blood assays. We are joined by world-renowned oncologist Dr. Margaret Tempero,UCSF Cancer Early Detection and Interception, to discuss whether these tests are truly ready for clinical prime time.

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Show Segments

  • 00:00 Introduction 
  • 01:57 Current Cancer Screening Programs 
  • 06:05 Emerging Blood-Based Cancer Tests 
  • 11:55 Test Characteristics and Limitations 
  • 18:05 Practical Considerations for Patients 
  • 25:33 Direct-to-Consumer Testing/Whole Body MRIs
  • 36:46 Navigating Positive Test Results 
  • 45:10 Anxiety and Patient Education 
  • 47:08 Future Directions in Cancer Screening 
  • Outro

Credits

  • Producer, Writer, Show Notes, Infographic, Cover Art: Molly Heublein MD
  • Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP   
  • Reviewer: Sai S Achi MD,MBA,FACP
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Technical Production: PodPaste
  • Guest: Margaret Tempero, MD


Disclosures

Dr. Tempero reports the following financial relationships:
Grail (research support), Global Bio Access Fund (Advisor), Bristol Myers Squibb (Membership on Advisory Committees or Review Panels, Board Membership, etc.), Astra Zeneca (Membership on Advisory Committees or Review Panels, Board Membership, etc), Immunovia (Membership on Advisory Committees or Review Panels, Board Membership, etc.), Merck (advisory committee), Renovo Rx (advisory committee), Urogen (Advisor). Financial relationships have not ended.
The Curbsiders report no relevant financial disclosures. 

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Tune in to The Curbsiders Internal Medicine Podcast for a direct line to practical clinical knowledge and the ever-evolving art of patient care. This isn't a dry lecture series; it's a dynamic conversation among practicing physicians who break down complex topics into actionable insights you can use. Each episode delves into the nuances of internal medicine, from managing common chronic conditions to interpreting the latest guidelines and navigating diagnostic dilemmas. You'll hear honest discussions about challenges at the bedside, evidence-based debates, and expert interviews that go beyond textbook summaries to reveal how medicine works in the real world. The podcast serves as both a continuing education resource and a professional companion, offering thoughtful analysis and clinical pearls that resonate whether you're a seasoned hospitalist, a resident in training, or a primary care provider. The focus is consistently on deepening understanding and improving daily practice, making the rounds or the clinic day feel a little less daunting and a lot more informed. Listen for a blend of curiosity, camaraderie, and a genuine commitment to mastering the craft of medicine, all delivered through engaging dialogue that feels like consulting with a trusted colleague.
Author: Language: English Episodes: 100

The Curbsiders Internal Medicine Podcast
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