Jens Juul Holst on the gut hormone discovery behind weight-loss drugs

Jens Juul Holst on the gut hormone discovery behind weight-loss drugs

Author: BBC Radio 4 April 14, 2026 Duration: 28:25

As recently as a few years ago, the idea of a self-administered injection that would deliver proven weight-loss results might have sounded fantastical. Today, these medications are a reality and a global phenomenon; hailed in many quarters as “miracle drugs" for their success in treating obesity and diabetes.

They do this by replicating a gut hormone called GLP‑1, which tells the brain you’ve eaten enough and nudges the pancreas to release insulin; and this hormone was discovered and decoded thanks to years of work by today's guest.

Jens Juul Holst is a Professor of Medical Physiology and Biomedical Sciences at the University of Copenhagen. His efforts laid the groundwork for today’s weight loss jabs, earning him a slew of high-profile accolades and awards. Now it seems they might not only have positive impacts on obesity and diabetes, but also other health issues...

But alongside the big success comes some big questions: including concerns over side effects, weight regain post-treatment, the black market in such drugs, and their cost and accessibility.

In a frank conversation with Professor Jim Al-Khalili, Jens address these issues and shares his hopes for the future of GLP-1-focused research.

Presented by Jim Al-Khalili Produced by Lucy Taylor A BBC Studios production


Hosted by physicist and author Professor Jim Al-Khalili, The Life Scientific offers a rare and intimate glimpse into the minds shaping our world. Each conversation moves beyond the standard lecture or interview, weaving together personal history with groundbreaking ideas. You’ll hear how childhood curiosity, unexpected setbacks, and moments of sheer luck have steered the careers of some of today's most influential researchers. This BBC Radio 4 podcast treats science not as a remote collection of facts, but as a deeply human endeavor driven by passion, perseverance, and sometimes, serendipity. The discussions delve into the real process of discovery-the late-night frustrations, the collaborative breakthroughs, and the ethical questions that arise from new knowledge. While exploring everything from the smallest particles to the vastness of the cosmos, the core of each episode remains the individual behind the science. Listeners come to understand not just what these scientists know, but who they are and what continues to drive them forward. It’s a series that connects the personal to the universal, making complex fields accessible and profoundly relevant. By focusing on the life as much as the science, this podcast reveals how our future is being built, one question at a time, in labs, field stations, and offices around the globe.
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