Sir Magdi Yacoub on pioneering heart transplant surgery

Sir Magdi Yacoub on pioneering heart transplant surgery

Author: BBC Radio 4 March 18, 2025 Duration: 28:35

What does it take to earn the nickname, ‘The Leonardo da Vinci of heart surgery’?

That's the moniker given to today's guest - a man who pioneered high-profile and often controversial procedures, but also helped drive huge medical progress; carrying out around 2,000 heart transplants and 400 dual heart-lung transplants during his 60-year career.

Sir Magdi Yacoub is Emeritus Professor of Cardiothoracic Surgery at Imperial College London, and Director of Research at Harefield Hospital’s Magdi Yacoub Institute. Inspired by a surgeon father and impacted by the tragic early death of his aunt from a heart condition, his medical career includes various surgical firsts alongside numerous research projects, to further our understanding of and ability to treat heart disease. He headed up the teams that discovered it is possible to reverse heart failure, and that successfully grew part of a human heart valve from stem cells for the first time.

But it hasn't always been plain sailing. At times, his work – such as early, unsuccessful transplant attempts, or using a baboon as a life-support system for a baby – attracted serious public criticism.

Speaking to Professor Jim Al-Khalili, Sir Magdi reflects on the highs and lows of his cardio career, and offers his advice to the next generation of surgeons and researchers hoping to make their mark in heart medicine.

Presented by Jim Al-Khalili Produced by Lucy Taylor


Hosted by physicist and author Professor Jim Al-Khalili, The Life Scientific offers a rare and intimate glimpse into the minds shaping our world. Each conversation moves beyond the standard lecture or interview, weaving together personal history with groundbreaking ideas. You’ll hear how childhood curiosity, unexpected setbacks, and moments of sheer luck have steered the careers of some of today's most influential researchers. This BBC Radio 4 podcast treats science not as a remote collection of facts, but as a deeply human endeavor driven by passion, perseverance, and sometimes, serendipity. The discussions delve into the real process of discovery-the late-night frustrations, the collaborative breakthroughs, and the ethical questions that arise from new knowledge. While exploring everything from the smallest particles to the vastness of the cosmos, the core of each episode remains the individual behind the science. Listeners come to understand not just what these scientists know, but who they are and what continues to drive them forward. It’s a series that connects the personal to the universal, making complex fields accessible and profoundly relevant. By focusing on the life as much as the science, this podcast reveals how our future is being built, one question at a time, in labs, field stations, and offices around the globe.
Author: Language: English Episodes: 50

The Life Scientific
Podcast Episodes
Kevin Fong on medical planning for Mars and Earth-based emergencies [not-audio_url] [/not-audio_url]

Duration: 28:39
There can't be many people in the world who've saved lives in hospital emergency rooms and also helped care for the wellbeing of astronauts in space – but Kevin Fong’s career has followed a singular path: from astrophysi…
Dame Pratibha Gai on training atoms to do what we want [not-audio_url] [/not-audio_url]

Duration: 28:23
Chemical reactions are the backbone of modern society: the energy we use, the medicines we take, our housing materials, even the foods we eat, are created by reacting different substances together. If we zoom in, it’s th…
Catherine Heymans on the lighter side of the dark universe [not-audio_url] [/not-audio_url]

Duration: 28:34
Have you ever considered the lighter side of dark matter? Comedy has proved an unexpectedly succesful way to engage people with science - as today's guest knows first-hand. Astrophysicist Catherine Heymans is a Professor…
Tim Coulson on how predators shape ecosystems and evolution [not-audio_url] [/not-audio_url]

Duration: 28:36
As a young man, traveling in Africa, Tim Coulson - now Professor of Zoology at the University of Oxford - became seriously ill with malaria and was told a second bout would probably kill him. Aged only 20, this brush wit…
Claudia de Rham on playing with gravity [not-audio_url] [/not-audio_url]

Duration: 28:21
Claudia de Rham has rather an unusual relationship with gravity. While she has spent her career exploring its fundamental nature, much of her free time has involved trying to defy it - from scuba diving in the Indian Oce…
Liz Morris on Antarctic adventures and the melting polar ice sheets [not-audio_url] [/not-audio_url]

Duration: 28:28
A frozen, white world at the far-reaches of the globe, where you're surrounded by snow and silence, might sound rather appealing. Factor in temperatures that drop to -57°C and a few of us might be put off - but for glaci…
Anthony Fauci on a medical career navigating pandemics and presidents [not-audio_url] [/not-audio_url]

Duration: 45:05
Welcome to a world where medicine meets politics: a space that brings together scientific research, government wrangling, public push-back and healthcare conspiracies…Dr Anthony Fauci was the Director of America’s Nation…