350: How Cortisol, Stress & Incretins Shape Metabolism: Understanding GLP‑1, GLP‑2, GIP & TriGLP Support

350: How Cortisol, Stress & Incretins Shape Metabolism: Understanding GLP‑1, GLP‑2, GIP & TriGLP Support

Author: The Natural Alternative - with Madonna Guy ND May 6, 2026 Duration: 8:13

Madonna Guy from The Natural Alternative delivered a deep dive into how chronic stress, trauma, and elevated cortisol disrupt the body’s metabolic signalling systems—particularly the incretin hormones GLP‑1, GLP‑2, and GIP. She explained how persistent cortisol elevation drives insulin resistance, weakens gut–brain communication, and creates a cycle of hunger without satisfaction, fatigue after meals, and difficulty losing weight. This metabolic loop, she noted, often leaves people feeling overwhelmed, inflamed, and stuck despite their best efforts.

The discussion explored how specific foods can either elevate or reduce cortisol, and how nutrient‑dense, fibre‑rich, fermented, and bitter foods naturally support the incretin system. Madonna highlighted that while these foods still help people with incretin or insulin resistance, the benefits may be muted until underlying stress and trauma are addressed. She also spoke about the limitations of GLP‑1 agonist medications, including potential muscle and collagen loss, and emphasised the importance of holistic approaches that support emotional wellbeing, gut repair, and long‑term metabolic balance.

To support individuals seeking deeper healing, Madonna shared information about holistic counselling sessions and bioresonance scanning, both designed to help regulate the nervous system and address emotional blocks that contribute to metabolic dysregulation. She also introduced TriGLP as a natural option for supporting gut health, nutrient absorption, and healthy weight management.

Website to Order TriGLP
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Madonna Guy brings a thoughtful and grounded perspective to the often noisy world of wellness in The Natural Alternative. As a practicing naturopath, she sits down with a diverse range of experts-from scientists and researchers to seasoned practitioners in various fields-to explore the practical intersections of traditional wisdom and modern evidence. This isn't about quick fixes or extreme ideologies; instead, each conversation unfolds like a deep dive into how our bodies and minds truly work. You'll hear discussions that thoughtfully examine nutrition, mental well-being, sustainable fitness, and the science behind holistic practices, all aimed at empowering informed choices. The tone is curious and conversational, making complex topics accessible without oversimplifying them. Tune into this podcast for a refreshingly balanced take on health, where the goal is building a resilient and vibrant life through understanding, not dogma. Madonna's approach makes The Natural Alternative a trusted space for anyone looking to move beyond the headlines and cultivate a personal sense of vitality.
Author: Language: English Episodes: 100

The Natural Alternative - with Madonna Guy
Podcast Episodes